ArticleJournal of atherosclerosis and thrombosis2019
Prognostic Value of International Normalized Ratio in Ischemic Stroke Patients without Atrial Fibrillation or Anticoagulation Therapy.
Article in Journal of atherosclerosis and thrombosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The performance of machine learning for predicting the recurrent stroke: a systematic review and meta-analysis on 24,350 patients.Acta neurologica Belgica · 2025Pooled it
- Effect of INR on Outcomes of Endovascular Treatment for Acute Vertebrobasilar Artery Occlusion.Translational stroke research · 2024Article
- Development and validation of a machine learning-based prognostic risk stratification model for acute ischemic stroke.Scientific reports · 2023Article
- The association between prothrombin time-international normalized ratio and long-term mortality in patients with coronary artery disease: a large cohort retrospective study with 44,662 patients.BMC cardiovascular disorders · 2022Article
- Novel Predictors of Stroke-Associated Pneumonia: A Single Center Analysis.Frontiers in neurology · 2022Article
- Residual Risk and Its Risk Factors for Ischemic Stroke with Adherence to Guideline-Based Secondary Stroke Prevention.Journal of stroke · 2021Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe impact of international normalized ratio (INR) on prognosis after acute ischemic stroke without anticoagulation therapy is unclear. Herein, the association between baseline INR and stroke outcomes in patients without anticoagulation therapy was investigated.
methodsA total of 14,782 ischemic stroke patients from the China National Stroke Registry Ⅱ were included in this analysis. The period of follow-up was 1 year after stroke onset. Multivariate logistic regression models were used to estimate the relationship between INR and stroke outcomes including all-cause death, recurrent stroke, composite end point, and poor functional outcome.
resultsOf 14,782 patients with stroke, all-cause death occurred in 1080 (7.3%), recurrence stroke in 538 (3.9%), combined end point in 1319 (8.9%), and poor functional outcome in 3001 (20.3%). Compared with the medium INR group (0.9-1.1), the odds ratios with confidence intervals of 95% for the high INR group (＞1.1) were 1.58 (1.32-1.98) for all-cause death, 1.40 (1.10-1.79) for stroke recurrence, 1.52 (1.29-1.79) for combined end point, and 1.21 (1.06-1.39) for poor functional outcome. No association between low INR (＜0.9) and any stroke outcomes was found compared with the medium group.
conclusionsIncreased admission INR was associated with adverse stroke outcomes among acute ischemic stroke patients without atrial fibrillation or anticoagulation therapy.
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