Evidence map›Paper›PMID 30318370›Full record

Observational studyThe Journal of pediatrics2018

HIV Exposure and Formula Feeding Predict Under-2 Mortality in HIV-Uninfected Children, Botswana.

Gbolahan Ajibola, Jean Leidner, Gloria K Mayondi, Erik van Widenfelt, Tebogo Madidimalo, Chipo Petlo, Sikhulile Moyo, Mompati Mmalane, Paige L Williams, Adam R Cassidy and 3 more

Abstract readObservational Study
In one paragraph

Observational study in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Gbolahan AjibolaBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana. Electronic address: gajibola@bhp.org.bw.
Jean LeidnerGoodtables Consulting, Norman, OK.
Gloria K MayondiBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Erik van WidenfeltBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Tebogo MadidimaloHIV Prevention Unit, Ministry of Health, Botswana.
Chipo PetloHIV Prevention Unit, Ministry of Health, Botswana.
Sikhulile MoyoBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
Mompati MmalaneBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana.
Paige L WilliamsDepartment of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA.
Adam R CassidyHarvard Medical School, Boston, MA; Department of Psychiatry, Boston Children's Hospital, Boston, MA.
Roger ShapiroBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA.
Betsy KammererHarvard Medical School, Boston, MA; Department of Psychiatry, Boston Children's Hospital, Boston, MA.
Shahin LockmanBotswana Harvard AIDS Institute Partnership, Gaborone, Botswana; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA; Harvard Medical School, Boston, MA; Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA.
Botswana Harvard AIDS Institute Partnership · BWHarvard University · USBoston Children's Hospital · USMinistry of Health · BWBrigham and Women's Hospital · US

Funding

Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
Training in HIV Genomics, Treatment, and Cure Research in BotswanaD43TW009610 · FIC · THE BOTSWANA HARVARD HEALTH PARTNERSHIP · PI SHAHIN LOCKMAN, Joseph Moeketsi Makhema · 2013 to 2026
$4.4M
Effects of HIV and ARV Exposure on Child Health and Neurodevelopment in Botswana.R01MH087344 · NIMH · HARVARD SCHOOL OF PUBLIC HEALTH · PI KAMMERER, BETSY, LOCKMAN, SHAHIN · 2009 to 2013
$2.9M
Mentoring in Patient-Oriented HIV Research in the Era of Universal ARTK24AI131928 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAHIN LOCKMAN · 2017 to 2026
$1.9M
Expansion of research and mentoring to improve birth outcomes and treatment outcomes among HIV-affected children in BotswanaK24AI131924 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Roger L Shapiro · 2018 to 2026
$1.6M
FIC NIH HHS D43 TW009610FIC NIH HHS D43 TW010543NIAID NIH HHS K24 AI131924NIAID NIH HHS K24 AI131928NIMH NIH HHS R01 MH087344
6 · The paper itself

Abstract

objectivesTo prospectively assess rates and detailed predictors of morbidity and mortality among HIV-exposed uninfected children and HIV-unexposed children in Botswana in a more recent era. STUDY

designWe enrolled HIV-infected and HIV-uninfected mothers and their children in the prospective observational Tshipidi study at 2 sites (1 city and 1 village) in Botswana from May 2010-July 2012. Live-born children and their mothers were followed for 24 months postpartum. Detailed sociodemographic data, health, and psychosocial characteristics were collected at baseline and prospectively, and health outcomes ascertained. Mothers chose infant feeding method with counselling.

resultsA total of 893 live-born HIV-uninfected children (436 HIV-exposed uninfected, 457 HIV-unexposed) were followed. HIV-infected mothers had a median CD4 count of 410 cells/mm

conclusionsThe strongest predictors of 24-month mortality among children in Botswana were HIV exposure and formula feeding, although the relative contribution of these factors to child health could not be separated.

Indexed as

Infant FormulaInfant MortalityPrenatal Exposure Delayed EffectsAdultAnti-Retroviral AgentsBotswanaCD4 Lymphocyte CountCongenital AbnormalitiesFemaleHIV InfectionsHumansInfantInfant, Low Birth WeightInfant, NewbornPregnancyPregnancy Complications, InfectiousAnti-Retroviral AgentsHIV exposed-uninfectedHIV unexposedmorbiditymortality

Identifiers

PMID30318370
PMCPMC6252117
OpenAlexW2897366126

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.