ArticleCell metabolism2019
Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 64 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
64 citing papers in PubMed, 1 synthesis or guideline pooled it, 137 citations in OpenAlex.
- Mortality Risk of Antidiabetic Agents for Type 2 Diabetes With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in endocrinology · 2021Pooled it
- Metformin in skin diseases: the role of gut microbiota and immune response.Pharmacological reports : PR · 2026Review
- Repurposing metformin as a dual-function agent to combat E. coli-induced mastitis: Mechanistic insights into biofilm dispersion and AMPK/SIRT1-mediated NF-κB inhibition.PLoS pathogens · 2026Article
- PMAntioxidants (Basel, Switzerland) · 2026Article
- Environmental modulators of vascular physiology and inflammation.Experimental physiology · 2026Review
- Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1.Immunometabolism (Cobham, Surrey) · 2026Article
- Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology.Nature metabolism · 2025Article
- Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis.Microbiology spectrum · 2025Article
- From Diabetes to Degenerative Diseases: The Multifaceted Action of Metformin.International journal of molecular sciences · 2025Review
- Metformin improves CD8+ T cell responses and parasitemia control via macrophage modulation during Trypanosoma cruzi infection.Journal of leukocyte biology · 2025Article
- A comprehensive review/expert statement on environmental risk factors of cardiovascular disease.Cardiovascular research · 2025Review
- Immunoregulatory effect of metformin in monocytes exposed to SARS-CoV-2 spike protein subunit 1.bioRxiv : the preprint server for biology · 2025Article
- Particulate matter air pollution: effects on the respiratory system.The Journal of clinical investigation · 2025Review
- Mitochondria dysfunction: cause or consequence of physiologic aging?Genes & development · 2025Review
- Mitochondrial respiratory complex III sustains IL-10 production in activated macrophages and promotes tumor-mediated immune evasion.Science advances · 2025Article
- Platelet signaling in immune landscape: comprehensive mechanism and clinical therapy.Biomarker research · 2024Review
- Metformin targets mitochondrial complex I to lower blood glucose levels.Science advances · 2024Article
- Inflammation: The Cause of All Diseases.Cells · 2024Article
- Vitamin D ameliorates particulate matter induced mitochondrial damages and calcium dyshomeostasis in BEAS-2B human bronchial epithelial cells.Respiratory research · 2024Article
- Particulate Matter-Induced Neurotoxicity: Unveiling the Role of NOX4-Mediated ROS Production and Mitochondrial Dysfunction in Neuronal Apoptosis.International journal of molecular sciences · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
32 authors at 4 institutions in 2 countries.
Saul SoberanesDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Alexander V MisharinDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Amit JairamanDepartment of Pharmacology, Northwestern University, Chicago, IL 60611, USA.
Luisa Morales-NebredaDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Alexandra C McQuattie-PimentelDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Takugo ChoDepartment of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA.
Robert B HamanakaDepartment of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA.
Angelo Y MelitonDepartment of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA.
Paul A ReyfmanDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
James M WalterDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Ching-I ChenDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Monica ChiDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Stephen ChiuDepartment of Surgery, Northwestern University, Chicago, IL 60611, USA.
Francisco J Gonzalez-GonzalezDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Matthew AntalekRice Institute for Biomedical Research, Department of Molecular Biosciences, Northwestern University, Evanston, IL 60201, USA.
Hiam Abdala-ValenciaDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Sergio E ChiarellaDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Kaitlyn A SunDepartment of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA.
Parker S WoodsDepartment of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA.
Andrew J GhioUnited States Environmental Protections Agency, Chapel Hill, NC 27599, USA.
Manu JainDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Harris PerlmanDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Karen M RidgeDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Richard I MorimotoRice Institute for Biomedical Research, Department of Molecular Biosciences, Northwestern University, Evanston, IL 60201, USA.
Jacob I SznajderDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
William E BalchScripps Research, Department of Molecular Medicine, La Jolla, CA 92037, USA.
Sangeeta M BhoradeDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Ankit BharatDepartment of Surgery, Northwestern University, Chicago, IL 60611, USA.
Murali PrakriyaDepartment of Pharmacology, Northwestern University, Chicago, IL 60611, USA.
Navdeep S ChandelDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA.
Gökhan M MutluDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA; Department of Medicine, University of Chicago, 5841 S Maryland Avenue, MC6026, Chicago, IL 60637, USA. Electronic address: gmutlu@medicine.bsd.uchicago.edu.
G R Scott BudingerDepartment of Medicine and Pulmonary and Critical Care Medicine, Northwestern University, 240 E Huron Street, M300, Chicago, IL 60611, USA. Electronic address: s-buding@northwestern.edu.
Northwestern University · USUniversity of Chicago · USEnvironmental Protection Agency · USScripps Institution of Oceanography · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MRole of LUBAC and Na K-ATPase in Acute Lung InjuryP01HL071643 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2003 to 2019
$30.8MTissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2015 to 2026
$26.9MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MTraining Program In Lung SciencesT32HL076139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE, Jacob I Sznajder · 2004 to 2026
$9.6MMitochondrial metabolism and ROS regulate cancerR35CA197532 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CHANDEL, NAVDEEP S · 2016 to 2022
$6.3MRole of alveolar macrophages in particulate matter-induced cardiopulmonary diseaseR01ES015024 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2006 to 2022
$6.1MStore-Operated Channels in the Nervous SystemR01NS057499 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PRAKRIYA, MURALI · 2007 to 2022
$5.4MThe injurious effects of hypercapnia on the alveolar epitheliumR01HL085534 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2006 to 2018
$4.9MRole and Regulation of Sodium, Potasium ATPase in LungR37HL048129 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2008 to 2017
$4.0MSignaling in the lung induced by particulate matter air pollutionR01ES013995 · NIEHS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BUDINGER, GR SCOTT · 2006 to 2015
$3.3MEffects of Hypoxia on Alveolar Epithelial CytoskeletonR01HL079190 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI RIDGE, KAREN M · 2005 to 2013
$3.1MBLRD VA I01 BX000201CSRD VA I01 CX001777NCI NIH HHS P30 CA060553NCI NIH HHS R35 CA197532NHLBI NIH HHS K08 HL125940NHLBI NIH HHS K08 HL128867NHLBI NIH HHS P01 HL071643NHLBI NIH HHS R01 HL048129NHLBI NIH HHS R01 HL079190NHLBI NIH HHS R01 HL085534NHLBI NIH HHS R01 HL124664NHLBI NIH HHS R01 HL128194NHLBI NIH HHS R01 HL134375NHLBI NIH HHS R37 HL048129NHLBI NIH HHS R56 HL135124NHLBI NIH HHS T32 HL076139NIAMS NIH HHS K01 AR066579NIAMS NIH HHS R01 AR064546NIAMS NIH HHS R03 AR061593NIA NIH HHS P01 AG049665NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01 ES013995NIEHS NIH HHS R01 ES015024NIEHS NIH HHS R21 ES025644NIEHS NIH HHS U01 ES026718NIGMS NIH HHS R01 GM114210NINDS NIH HHS R01 NS057499
Abstract
Urban particulate matter air pollution induces the release of pro-inflammatory cytokines including interleukin-6 (IL-6) from alveolar macrophages, resulting in an increase in thrombosis. Here, we report that metformin provides protection in this murine model. Treatment of mice with metformin or exposure of murine or human alveolar macrophages to metformin prevented the particulate matter-induced generation of complex III mitochondrial reactive oxygen species, which were necessary for the opening of calcium release-activated channels (CRAC) and release of IL-6. Targeted genetic deletion of electron transport or CRAC channels in alveolar macrophages in mice prevented particulate matter-induced acceleration of arterial thrombosis. These findings suggest metformin as a potential therapy to prevent some of the premature deaths attributable to air pollution exposure worldwide.
Indexed as
Air PollutionAnimalsCell LineCytokinesElectron TransportHumansInterleukin-6Lung DiseasesMacrophages, AlveolarMaleMetforminMiceMice, Inbred C57BLMitochondriaParticulate MatterReactive Oxygen SpeciesCytokinesInterleukin-6MetforminParticulate MatterReactive Oxygen Speciesair pollutioncalcium channelselectron transport chainmitochondriaproteostasisreactive oxygen speciessignalingthrombosis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.