ArticleSeminars in arthritis and rheumatism2019
Vascular calcification in patients with large-vessel vasculitis compared to patients with hyperlipidemia.
Article in Seminars in arthritis and rheumatism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 29 citations in OpenAlex.
- The Etiology of Intracranial Artery Stenosis in Autoimmune Rheumatic Diseases: An Observational High-Resolution MR Imaging Study.AJNR. American journal of neuroradiology · 2025Observational
- Association between premature vascular smooth muscle cells senescence and vascular inflammation in Takayasu's arteritis.Annals of the rheumatic diseases · 2024Article
- Takayasu arteritis with recurrent coronary artery disease.Indian journal of thoracic and cardiovascular surgery · 2024Article
- Association between a body shape index and cognitive impairment among US older adults aged 40 years and above from a cross-sectional survey of the NHANES 2011-2014.Frontiers in endocrinology · 2024Article
- Isolated Coronary Arteritis in Adults: a Single-Center Experience from China.Journal of cardiovascular translational research · 2023Article
- Article
- IgG4-related disease as a variable-vessel vasculitis: A case series of 13 patients with medium-sized coronary artery involvement.Seminars in arthritis and rheumatism · 2023Article
- Use of high-plex data provides novel insights into the temporal artery processes of giant cell arteritis.Frontiers in immunology · 2023Article
- Serum levels of fetuin-A as a novel biomarker for disease activity in patients with Takayasu arteritis and granulomatous polyangiitis.Clinical rheumatology · 2022Article
- Single-Cell Transcriptome Analysis Reveals Embryonic Endothelial Heterogeneity at Spatiotemporal Level and Multifunctions of MicroRNA-126 in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2022Article
- Atherosclerotic Plaque Burden on Abdominal CT: Automated Assessment With Deep Learning on Noncontrast and Contrast-enhanced Scans.Academic radiology · 2021Article
- Risk factors for symptomatic vascular events in giant cell arteritis: a study of 254 patients with large-vessel imaging at diagnosis.Therapeutic advances in musculoskeletal disease · 2021Article
- Tocilizumab treatment effectively improves coronary artery involvement in patients with Takayasu arteritis.Clinical rheumatology · 2020Article
- A study on the risk factors of coronary artery disease in patients with Takayasu arteritis.Journal of thoracic disease · 2020Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveCalcification of the coronary arteries, aorta, and branch vessels can occur in both large-vessel vasculitis (LVV) and atherosclerosis. The study objective was to determine the location and amount of vascular calcification in patients with LVV versus hyperlipidemia (HLD) and to identify risk factors associated with vascular calcification in LVV.
methodsPatients with giant cell arteritis (GCA), Takayasu's arteritis (TAK), and HLD underwent non-contrast computed tomography of the aorta and branch vessels. Vascular calcification in 14 specific arterial territories (4 segments of the aorta, 9 branch arteries, and the coronary arteries) was quantified throughout the large arteries by a cumulative Agatston score. Multivariate linear regression analyses were used to identify associations between traditional and disease-specific risk factors and total Agatston score.
resultsA total of 88 subjects, including GCA (n = 29); TAK (n = 22); and HLD (n = 37), participated. Prevalence of vascular calcification in the aorta and branch vessels significantly differed in the coronary arteries (HLD = 67%, GCA = 35%, TAK = 9%, p < 0.01). Total Agatston scores were higher in GCA (median 3260, range 25-18,138) versus HLD (460, 19-17,215) (p < 0.01) but did not significantly differ between GCA and TAK (1944, 52-47,520) (p = 0.53). In multivariable regression analysis, age, type of vasculitis, and prednisone use was associated with vascular calcification in LVV.
conclusionThe prevalence of coronary artery calcification is lower in LVV compared to HLD, but the amount of total vascular calcification throughout the large arteries is greater in LVV. Both traditional and disease-specific risk factors are associated with vascular calcification in LVV.
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