Evidence map›Paper›PMID 30317905›Full record

ArticleInfectious diseases (London, England)2019

Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men.

Andrew D Redd, Marie Helleberg, Matthew Sievers, Stephen D Schmidt, Nicole A Doria-Rose, Daniel Bruno, Shelby Traeger, Craig Martens, Jannik Fonager, Gitte Kronborg and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infectious diseases (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Andrew D Redda Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH , Bethesda , USA.
Marie Hellebergc Department of Infectious Diseases , Copenhagen University Hospital , Rigshospitalet , Denmark.
Matthew Sieversb Department of Medicine , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
Stephen D Schmidtd Vaccine Research Center, NIAID, NIH , Bethesda , MD , USA.
Nicole A Doria-Rosed Vaccine Research Center, NIAID, NIH , Bethesda , MD , USA.
Daniel Brunoe Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH , Hamilton , MT , USA.
Shelby Traegere Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH , Hamilton , MT , USA.
Craig Martense Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH , Hamilton , MT , USA.
Jannik Fonagerf Section for Virus Surveillance and Research, Department of Virus & Microbiological Special Diagnostics, Infectious Disease Preparedness , Statens Serum Institut , Copenhagen , Denmark.
Gitte Kronborgg Department of Infectious Diseases , Copenhagen University Hospital , Hvidovre , Denmark.
Zoe Packmanh Department of Pathology , Johns Hopkins University School of Medicine , Baltimore , MD , USA.
John R Mascolad Vaccine Research Center, NIAID, NIH , Bethesda , MD , USA.
Stephen F Porcellae Genomics Unit, Research Technologies Branch, Rocky Mountain Laboratories, Division of Intramural Research, NIAID, NIH , Hamilton , MT , USA.
Jan Gerstoftc Department of Infectious Diseases , Copenhagen University Hospital , Rigshospitalet , Denmark.
Thomas C Quinna Laboratory of Immunoregulation, Division of Intramural Research, NIAID, NIH , Bethesda , USA.
Johns Hopkins Medicine · USJohns Hopkins University · USRigshospitalet · DKCopenhagen University Hospital · DKStatens Serum Institut · DK

Funding

International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Intramural NIH HHS ZIA AI000361
6 · The paper itself

Abstract

backgroundThe role of the anti-HIV neutralizing antibody response in protecting against HIV superinfection, and changes in neutralizing antibody potency and breadth after HIV superinfection have not been fully elucidated. This study examined the rate of HIV superinfection in men who have sex with men (MSM) also diagnosed with syphilis in Denmark, and the anti-HIV neutralizing antibody response in men who became superinfected. MATERIALS AND

methodsMSM enrolled in the Danish HIV cohort who acquired syphilis were examined longitudinally for HIV superinfection using a validated next-generation sequencing assay. HIV superinfection cases were matched 3:1 to controls, and neutralizing antibody responses before (cases/controls) and after (cases) HIV superinfection were determined using a 20-pseudovirus panel.

resultsFour cases of HIV superinfection were identified from 95 MSM screened for a rate of HIV superinfection of 1.56/100 pys (95% CI = 0.43-4.01). Prior to HIV superinfection neutralizing antibody responses were low in breadth and potency, and did not differ between cases and controls (p = 1.0). In cases, neutralizing antibody responses increased modestly after HIV superinfection.

conclusionsThese data support the theory that the natural neutralizing antibody response to HIV infection may not be the controlling factor in protecting against a subsequent HIV challenge.

Indexed as

Homosexuality, MaleAntibodies, NeutralizingDenmarkHigh-Throughput Nucleotide SequencingHIVHIV AntibodiesHIV InfectionsHumansLongitudinal StudiesMaleProspective StudiesSuperinfectionSyphilisAntibodies, NeutralizingHIV AntibodiesDenmarkHIV superinfectionMSMNeutralizing antibody

Identifiers

PMID30317905
PMCPMC8319735
OpenAlexW2898078382

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.