Evidence map›Paper›PMID 30317900›Full record

ArticleNanotoxicology2018

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes.

Katherine S Duke, Elizabeth A Thompson, Mark D Ihrie, Alexia J Taylor-Just, Elizabeth A Ash, Kelly A Shipkowski, Jonathan R Hall, Debra A Tokarz, Mark F Cesta, Ann F Hubbs and 3 more

Open access · greenAbstract read
In one paragraph

Article in Nanotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Katherine S Dukea Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Elizabeth A Thompsona Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Mark D Ihriea Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Alexia J Taylor-Justa Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Elizabeth A Ashb College of Veterinary Medicine , North Carolina State University , Raleigh , NC , USA.
Kelly A Shipkowskia Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Jonathan R Halla Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
Debra A Tokarzb College of Veterinary Medicine , North Carolina State University , Raleigh , NC , USA.
Mark F Cestac National Institute of Environmental Health Sciences , Research Triangle Park , NC , USA.
Ann F Hubbsd National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Dale W Porterd National Institute for Occupational Safety and Health , Morgantown , WV , USA.
Linda M Sargentd National Institute for Occupational Safety and Health , Morgantown , WV , USA.
James C Bonnera Department of Biological Sciences , North Carolina State University , Raleigh , NC , USA.
North Carolina State University · USNational Institute for Occupational Safety and Health · USTriangle · US

Funding

Translational Research Support CoreP30ES025128 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Andrew R. Binder · 2015 to 2026
$18.3M
TRAINING IN BIOCHEMICAL AND ENVIRONMENTAL TOXICOLOGYT32ES007046 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI Seth William Kullman · 1985 to 2026
$5.1M
Genetic Susceptibility to Nanoparticle-Induced Respiratory DiseaseR01ES020897 · NIEHS · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BONNER, JAMES CHRISTOPHER · 2012 to 2017
$1.7M
Intramural CDC HHS CC999999NIEHS NIH HHS P30 ES025128NIEHS NIH HHS R01 ES020897NIEHS NIH HHS T32 ES007046
6 · The paper itself

Abstract

The fiber-like shape of multi-walled carbon nanotubes (MWCNTs) is reminiscent of asbestos, suggesting they pose similar health hazards when inhaled, including pulmonary fibrosis and mesothelioma. Mice deficient in the tumor suppressor p53 are susceptible to carcinogenesis. However, the chronic pathologic effect of MWCNTs delivered to the lungs of p53 heterozygous (p53

Indexed as

AnimalsDose-Response Relationship, DrugGranuloma, Respiratory TractInhalation ExposureLungMaleMiceMice, Inbred C57BLMice, KnockoutNanotubes, CarbonSurface PropertiesTertiary Lymphoid StructuresTumor Suppressor Protein p53Nanotubes, CarbonTrp53 protein, mouseTumor Suppressor Protein p53cancerCaron nanotubesgranulomaimmunotoxicologyp53

Identifiers

PMID30317900
PMCPMC6379105
OpenAlexW2897464461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.