ArticleJournal of personality2019
Intra-cortical myelin mediates personality differences.
Article in Journal of personality, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Reduced Gray-White Matter Contrast in Chronic Posttraumatic Stress Disorder in World Trade Center Responders.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Cortical modulation of resting state BOLD signals in white matter.Scientific reports · 2025Article
- The Effects of Loving-Kindness Meditation Guided by Short Video Apps on Policemen's Mindfulness, Public Service Motivation, Conflict Resolution Skills, and Communication Skills.Behavioral sciences (Basel, Switzerland) · 2025Article
- Intracortical Myelin in Youths at Risk for Depression.Biological psychiatry global open science · 2024Article
- Openness and age influence cognitive progression: a longitudinal study.Arquivos de neuro-psiquiatria · 2023Article
- The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Neurocircuitry of Personality Traits and Intent in Decision-Making.Behavioral sciences (Basel, Switzerland) · 2023Review
- Stress and the brain: Emotional support mediates the association between myelination in the right supramarginal gyrus and perceived chronic stress.Neurobiology of stress · 2023Article
- Empirical transmit field bias correction of T1w/T2w myelin maps.NeuroImage · 2022Article
- Linking interindividual variability in brain structure to behaviour.Nature reviews. Neuroscience · 2022Review
- "Nothing to see here": No structural brain differences as a function of thePersonality neuroscience · 2022Review
- Comparative connectomics of the primate social brain.NeuroImage · 2021Review
- The Association between Body Mass Index and Intra-Cortical Myelin: Findings from the Human Connectome Project.Nutrients · 2021Article
- Article
- Aberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls.NeuroImage. Clinical · 2021Article
- Individual Cortical Entropy Profile: Test-Retest Reliability, Predictive Power for Cognitive Ability, and Neuroanatomical Foundation.Cerebral cortex communications · 2020Article
- Intra-cortical myelin mediates personality differences.Journal of personality · 2019Article
- The Challenges of Diagnostic Imaging in the Era of Big Data.Journal of clinical medicine · 2019Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 3 countries.
Funding
Abstract
objectiveDifferences in myelination in the cortical mantle are important neurobiological mediators of variability in cognitive, emotional, and behavioral functioning. Past studies have found that personality traits reflecting such variability are linked to neuroanatomical and functional changes in prefrontal and temporo-parietal cortices. Whether these effects are partially mediated by the differences in intra-cortical myelin remains to be established.
methodTo test this hypothesis, we employed vertex-wise intra-cortical myelin maps in n = 1,003 people from the Human Connectome Project. Multivariate regression analyses were used to test for the relationship between intra-cortical myelin and each of the five-factor model's personality traits, while accounting for age, sex, intelligence quotient, total intracranial volume, and the remaining personality traits.
resultsNeuroticism negatively related to frontal-pole myelin and positively to occipital cortex myelin. Extraversion positively related to superior parietal myelin. Openness negatively related to anterior cingulate myelin, while Agreeableness positively related to orbitofrontal myelin. Conscientiousness positively related to frontal-pole myelin and negatively to myelin content in the dorsal anterior cingulate cortex.
conclusionsIntra-cortical myelin levels in brain regions with prolonged myelination are positively associated with personality traits linked to favorable outcome measures. These findings improve our understanding of the neurobiological underpinnings of variability in common behavioral dispositions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.