Evidence map›Paper›PMID 30317586›Full record

ArticleJournal of cellular physiology2019

A pH-sensitive luminal His-cluster promotes interaction of PAM with V-ATPase along the secretory and endocytic pathways of peptidergic cells.

Vishwanatha K Rao, Gerardo Zavala, Abhijit Deb Roy, Richard E Mains, Betty A Eipper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Peptidylglycine α-amidating monooxygenase is required for atrial secretory granule formation.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Vishwanatha K RaoDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut.ORCID 0000-0001-9471-807X
Gerardo ZavalaDepartment of Chemistry, University of Texas at El Paso, El Paso, Texas.
Abhijit Deb RoyRichard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut Health Center, Farmington, Connecticut.
Richard E MainsDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut.
Betty A EipperDepartment of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut.
UConn Health · USJohns Hopkins University · USThe University of Texas at El Paso · US

Funding

Yale/NIDA Neuroproteomics Research CenterP30DA018343 · NIDA · YALE UNIVERSITY · PI ANGUS C. NAIRN, Kenneth Robert WILLIAMS · 2004 to 2026
$37.1M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR01DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH ANNE, KING, STEPHEN M · 1986 to 2017
$6.4M
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR37DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 1989 to 2004
$2.8M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysiS10OD018521 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2015 to 2015
$890k
6500 QTrap Mass Spectrometer for Yale UniversityS10OD018034 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2014 to 2014
$514k
BIOCHEMISTRY AND PHYSIOLOGY OF PEPTIDE AMIDATIONR56DK032949 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI EIPPER, ELIZABETH A · 2005 to 2005
$104k
NIDA NIH HHS P30 DA018343NIDDK NIH HHS R01 DK032949NIDDK NIH HHS R37 DK032949NIDDK NIH HHS R56 DK032949NIH HHS S10 OD018034NIH HHS S10 OD018521
6 · The paper itself

Abstract

The biosynthetic and endocytic pathways of secretory cells are characterized by progressive luminal acidification, a process which is crucial for posttranslational modifications and membrane trafficking. This progressive fall in luminal pH is mainly achieved by the vacuolar-type-H

Indexed as

EndocytosisAnimalsCell LineFemaleHydrogen-Ion ConcentrationMaleMiceMice, Inbred C57BLMixed Function OxygenasesMultienzyme ComplexesMutationNeuroendocrine CellsProrenin ReceptorProtein BindingProtein Interaction Domains and MotifsProtein Structure, TertiaryAtp6ap1 protein, mouseATP6AP2 protein, mouseMixed Function OxygenasesMultienzyme Complexespeptidylglycine monooxygenaseProrenin ReceptorProton-Translocating ATPasesReceptors, Cell SurfaceVacuolar Proton-Translocating ATPasesAtT-20blue native PAGEcorticotrope tumor cellshistidine clusterluminal pHproton pumpsubcellular fractionation

Identifiers

PMID30317586
PMCPMC6395498
OpenAlexW2897506399

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.