ArticleJournal of neurology2018
Elevated C-reactive protein and white blood cell count at admission predict functional outcome after non-aneurysmal subarachnoid hemorrhage.
Article in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Frailty diminishes functional outcome in patients with nonaneurysmal subarachnoid hemorrhage: a dual specialized neurovascular center analysis.Journal of neurology · 2025Article
- Article
- Association of inflammatory trajectory with subarachnoid hemorrhage mortality.Neurosurgical review · 2024Article
- Development of a predictive nomogram for 28-day mortality risk in non-traumatic or post-traumatic subarachnoid hemorrhage patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Development and validation of a prediction tool for intraoperative blood transfusion in brain tumor resection surgery: a retrospective analysis.Scientific reports · 2023Article
- Prognostic Value of C-Reactive Protein and Albumin in Neurocritically Ill Patients with Acute Stroke.Journal of clinical medicine · 2022Article
- XGBoost Machine Learning Algorithm for Prediction of Outcome in Aneurysmal Subarachnoid Hemorrhage.Neuropsychiatric disease and treatment · 2022Article
- Prolonged Mechanical Ventilation in Patients with Deep-Seated Intracerebral Hemorrhage: Risk Factors and Clinical Implications.Journal of clinical medicine · 2021Article
- Prognostic Value of Preoperative Inflammatory Markers in Melanoma Patients with Brain Metastases.Journal of clinical medicine · 2021Article
- Association of Plasma Glucose to Potassium Ratio and Mortality After Aneurysmal Subarachnoid Hemorrhage.Frontiers in neurology · 2021Article
- Lectin complement pathway initiators after subarachnoid hemorrhage - an observational study.Journal of neuroinflammation · 2020Observational
- Predictive Value of Routine Peripheral Blood Biomarkers in Alzheimer's Disease.Frontiers in aging neuroscience · 2019Article
- C-Reactive Protein/Albumin Ratio Correlates With Disease Severity and Predicts Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage.Frontiers in neurology · 2019Article
- Association between systemic inflammation biomarkers and outcomes in patients with aneurysmal subarachnoid hemorrhage.Frontiers in neurologyArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPatients with non-aneurysmal subarachnoid hemorrhage (SAH) are considered to have an overall benign course of disease compared to patients suffering from aneurysmal SAH. Nevertheless, a small but significant number of such patients might only achieve unfavorable outcome. Therefore, the purpose of the present study was to determine if routine laboratory markers of acute phase response are associated with unfavorable outcome in patients with non-aneurysmal SAH.
methodsFrom 2006 to 2017, 154 patients suffering from non-aneurysmal SAH were admitted to our institution. Patients were stratified according to the distribution of cisternal blood into patients with perimesencephalic SAH (pSAH) versus non-perimesencephalic SAH (npSAH). C-reactive protein (CRP) and white blood cells (WBC) assessments were performed within 24 h of admission as part of routine laboratory workup. Outcome was assessed according to the modified Rankin Scale (mRS) after 6 months and stratified into favorable (mRS 0-2) vs. unfavorable (mRS 3-6).
resultsThe multivariate regression analysis revealed "CRP > 5 mg/l" (p = 0.004, OR 143.7), "WBC count > 12.1 G/l" (p = 0.006, OR 47.8), "presence of IVH" (p = 0.02, OR 13.5), "poor-grade SAH" (p = 0.01, OR 45.2) and "presence of CVS" (p = 0.003, OR 149.9) as independently associated with unfavorable outcome in patients with non-aneurysmal SAH.
conclusionElevated C-reactive protein and WBC count at admission were associated with unfavorable outcome after non-aneurysmal SAH.
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