Trial reportHuman genetics2018
Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations.
Open access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph
Trial report in Human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
5.6field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Glaucoma Genetic Risk Scores in the Million Veteran Program.Ophthalmology · 2022Pooled it
- Eyes of Africa: The Genetics of Blindness. Baseline characteristics, ocular features, and associations with glaucoma in continental Africans.Eye (London, England) · 2026Article
- A Whole-Genome Sequence Genome-Wide Association Study inOphthalmology science · 2026Article
- Primary Open-Angle Glaucoma among Black and Latinx Populations: Exploring Racial Disparities in the United States.Journal of racial and ethnic health disparities · 2026Review
- Genetic Architecture of Trans-Laminar Cribrosa Pressure Difference and Primary Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2026Article
- Time to Blindness and Associated Factors Among Glaucoma Patients Under Treatment at Governmental Hospitals in Amhara Region, Ethiopia; Application of Gamma Shared Frailty Accelerate Failure Time Model.Health science reports · 2026Article
- Article
- Single-cell profiling of trabecular meshwork identifies mitochondrial dysfunction in a glaucoma model that is protected by vitamin B3 treatment.bioRxiv : the preprint server for biology · 2025Article
- Cross-Tissue Transcriptome-Wide Association Study Identifies Novel Genes Associated With POAG.Investigative ophthalmology & visual science · 2025Article
- Outcomes of Trabeculectomy and Predictors of Success in Patients of African Ancestry With Primary Open Angle Glaucoma.Journal of glaucoma · 2025Article
- Polymorphic variants ofInternational journal of ophthalmology · 2025Article
- Performance of Polygenic Risk Scores for Primary Open-Angle Glaucoma in Populations of African Descent.JAMA ophthalmology · 2025Article
- Article
- Primary open-angle glaucoma risk prediction with ABCA1 and LOC102723944 variants and their genotype-phenotype correlations in southern Chinese population.Molecular genetics and genomics : MGG · 2023Article
- Cholesterol and oxysterols in retinal neuron-glia interactions: relevance for glaucoma.Frontiers in ophthalmology · 2023Review
- Paving the way while playing catch up: mitochondrial genetics in African ancestry primary open-angle glaucoma.Frontiers in ophthalmology · 2023Article
- Personalizing medicine in Africa: current state, progress and challenges.Frontiers in genetics · 2023Review
- Review
- Genetic variants associated with glaucomatous visual field loss in primary open-angle glaucoma.Scientific reports · 2022Article
- The genetics of glaucoma: Disease associations, personalised risk assessment and therapeutic opportunities-A review.Clinical & experimental ophthalmology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors at 16 institutions in 8 countries.
Pieter W M BonnemaijerDepartment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
Adriana I IglesiasDepartment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
Girish N NadkarniThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Anna J SanyiwaDepartment of Ophthalmology, Muhimbili University of Health and Allied Sciences/Muhimbili National Hospital, Dar es Salaam, Tanzania.
Hassan G HassanDepartment of Ophthalmology, Comprehensive Community Based Rehabilitation in Tanzania (CCBRT) Hospital, Dar es Salaam, Tanzania.
Colin CookDivision of Ophthalmology, University of Cape Town, Cape Town, South Africa.
GIGA Study Group
Mark SimcoeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Kent D TaylorDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
Claudia SchurmannThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gillian M BelbinThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Eimear E KennyThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Erwin P BottingerThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Suzanne van de LaarDepartment of Ophthalmology, University Medical Center, Utrecht, The Netherlands.
Susan E I WiliamsDivision of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa.
Stephen K AkafoUnit of Ophthalmology, Department of Surgery, University of Ghana School of Medicine and Dentistry, Accra, Ghana.
Adeyinka O AshayeDepartment of Ophthalmology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Linda M ZangwillDepartment of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Christopher A GirkinDepartment of Ophthalmology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA.
Maggie C Y NgDepartment of Biochemistry, Center for Diabetes Research, Wake Forest School of Medicine, Winston-Salem, NC, USA.
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA, USA.
Robert N WeinrebDepartment of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California San Diego, La Jolla, CA, USA.
Zheng LiGenome Institute of Singapore, Singapore, Singapore.
R Rand AllinghamDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Eyes of Africa Genetics Consortium
Abhishek NagDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Pirro G HysiDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Magda A Meester-SmoorDepartment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
Janey L WiggsDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA.
NEIGHBORHOOD Consortium
Michael A HauserDepartment of Ophthalmology, Duke University, Durham, NC, USA.
Christopher J HammondDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Hans G LemijGlaucoma Service, The Rotterdam Eye Hospital, Rotterdam, The Netherlands.
Ruth J F LoosThe Charles Bronfman Institute of Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
Alberta A H J ThiadensDepartment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands. c.c.w.klaver@erasmusmc.nl.
Erasmus MC · NLThe Lundquist Institute · USDuke University · USIcahn School of Medicine at Mount Sinai · USKing's College London · GBHarvard University · USMuhimbili University of Health and Allied Sciences · TZRadboud University Nijmegen · NLUniversity of Alabama at Birmingham · USUniversity of Cape Town · ZAUniversity of Ghana · GHChild Health and Development Institute · USUniversity Medical Center Utrecht · NLUniversity of California San Diego · USUniversity of Ibadan · NGUniversity of the Witwatersrand · ZA
Funding
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4MP30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Janey L Wiggs · 2002 to 2026
$15.1MVision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3MThe NEIGHBORHOOD: POAG Heritable Overall Operational DatabaseR01EY022305 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI WIGGS, JANEY L · 2012 to 2025
$7.9MxADAGES III: Contribution of genotype to glaucoma phenotype in African AmericansR01EY023704 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROTTER, JEROME I, WEINREB, ROBERT N · 2013 to 2017
$6.3MGenetics of African American Type 2 DiabetesR01DK066358 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NG, MAGGIE · 2003 to 2019
$6.2MMAPPING GENES FOR NIDDM NEPHROPATHY IN AFRICAN AMERICANSR01DK053591 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BOWDEN, DONALD W · 1998 to 2015
$5.6MGenetic Analysis of African American Hypertensive End-Stage Renal DiseaseR01DK070941 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2006 to 2015
$4.7MDiverse ancestry biobank to map biomedical traits and elucidate health disparitieU01HG007417 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI LOOS, RUTH JF · 2013 to 2017
$3.5MDiagnostic Innovations in Glaucoma Study (DIGS): Functional ImpairmentR01EY021818 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MEDEIROS, FELIPE · 2011 to 2015
$3.4MGenetic Determinants of Adiposity in African AmericansR01DK087914 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI NG, MAGGIE · 2010 to 2014
$3.0MBrightFocus Foundation G2015084NCATS NIH HHS UL1 TR001881NEI NIH HHS EY019869NEI NIH HHS EY021818NEI NIH HHS EY023704NEI NIH HHS EY110008NEI NIH HHS P30 EY014104NEI NIH HHS P30 EY022589NEI NIH HHS P30EY022589NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY021818NEI NIH HHS R01 EY022305NEI NIH HHS R01EY022305NEI NIH HHS R01 EY023512NEI NIH HHS R01 EY023704NEI NIH HHS R21 EY028671NHGRI NIH HHS U01 HG007417NHGRI NIH HHS U01HG007417NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK053591NIDDK NIH HHS R01 DK066358NIDDK NIH HHS R01 DK070941NIDDK NIH HHS R01 DK087914NIDDK NIH HHS R01 DK101855NIDDK NIH HHS R01DK101855NIDDK NIH HHS R01 DK107786NIDDK NIH HHS R01DK107786NIDDK NIH HHS R01 DK110113NIDDK NIH HHS R01DK110113NIDDK NIH HHS U01 DK105556NIH HHS CTSI UL1TR001881NIH HHS DRC DK063491NIH HHS R01 HL56266NIH HHS S10 OD018164NIH HHS S10 OD018522
Abstract
Primary open angle glaucoma (POAG) is a complex disease with a major genetic contribution. Its prevalence varies greatly among ethnic groups, and is up to five times more frequent in black African populations compared to Europeans. So far, worldwide efforts to elucidate the genetic complexity of POAG in African populations has been limited. We conducted a genome-wide association study in 1113 POAG cases and 1826 controls from Tanzanian, South African and African American study samples. Apart from confirming evidence of association at TXNRD2 (rs16984299; OR
Indexed as
Genetic LociGenome-Wide Association StudyAgedAged, 80 and overBlack or African AmericanBlack PeopleFemaleGlaucoma, Open-AngleHumansMaleMiddle AgedThioredoxin Reductase 2Vesicular Transport ProteinsEXOC4 protein, humanThioredoxin Reductase 2TXNRD2 protein, humanVesicular Transport Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.