Observational studyPediatric nephrology (Berlin, Germany)2019
Common clinical markers predict end-stage renal disease in children with obstructive uropathy.
Observational study in Pediatric nephrology (Berlin, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- p90RSK modulates inter-and intracellular signaling in kidney diseases.Frontiers in cell and developmental biology · 2025Review
- Kidney disease progression in pediatric and adult posterior urethral valves (PUV) patients.Pediatric nephrology (Berlin, Germany) · 2024Article
- Congenital anomalies of the kidney and urinary tract: defining risk factors of disease progression and determinants of outcomes.Pediatric nephrology (Berlin, Germany) · 2023Review
- Predicting outcomes in children with congenital anomalies of the kidney and urinary tract.Pediatric nephrology (Berlin, Germany) · 2023Article
- Outcomes of solitary functioning kidneys-renal agenesis is different than multicystic dysplastic kidney disease.Pediatric nephrology (Berlin, Germany) · 2021Article
- Evaluation of polyuria and polydipsia along with other established prognostic factors in posterior urethral valves for progression to kidney failure: experience from a developing country.Pediatric nephrology (Berlin, Germany) · 2021Article
- Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery.Journal of clinical medicine · 2021Article
- Predicting outcomes and improving care in children with congenital kidney anomalies.Pediatric nephrology (Berlin, Germany) · 2020Article
- Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Clinical predictors of chronic kidney disease in congenital lower urinary tract obstruction.Pediatric nephrology (Berlin, Germany) · 2020Review
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundObstructive uropathy (OU) is a common cause of end-stage renal disease (ESRD) in children. Children who escape the newborn period with mild-to-moderate chronic kidney disease (CKD) continue to be at increased risk. The predictive ability of clinically available markers throughout childhood is poorly defined.
methodsPatients with OU were identified in the Chronic Kidney Disease in Children Study. The primary outcome of interest was renal replacement therapy (RRT) (cases). Controls were age matched and defined as patients within the OU cohort who did not require RRT during study follow-up.
resultsIn total, 27 cases and 41 age-matched controls were identified. Median age at baseline and age at outcome measurement were 10 vs. 16 years, respectively. First available glomerular filtration rate (GFR) (36.9 vs. 53.5 mL/min per 1.73 m
conclusionsAge-specific baseline and longitudinal measures of readily available clinical measures predict progression to ESRD in children with mild-to-moderate CKD from OU.
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