Evidence map›Paper›PMID 30317151›Full record

ReviewCurrent opinion in microbiology2018

Effector variation at tandem gene arrays in tissue-dwelling coccidia: who needs antigenic variation anyway?

Matthew L Blank, Jon P Boyle

Abstract readReview
In one paragraph

Review in Current opinion in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  3. Diversity ofFood and waterborne parasitology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew L BlankDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jon P BoyleDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: boylej@pitt.edu.

Funding

Effector diversification and Toxoplasma virulenceR01AI114655 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BOYLE, JON P · 2015 to 2019
$1.9M
NIAID NIH HHS R01 AI114655
6 · The paper itself

Abstract

Locus expansion and diversification is pervasive in apicomplexan genomes and is predominantly found in loci encoding secreted proteins that interact with factors outside of the parasite. Key for understanding the impact of each of these loci on the host requires identification and functional characterization of their protein products, but these repetitive loci often are refractory to genome assembly. In this review we focus on Toxoplasma gondii and its nearest relatives to highlight the known impact of duplicated and diversified loci on our understanding of the host-pathogen molecular arms race. We describe current tools used for the identification and characterization of these loci, and review the most recent examples of how gene-expansion driven diversification can lead to novel gene functions.

Indexed as

Antigenic VariationAnimalsHumansProtozoan ProteinsToxoplasmaToxoplasmosisProtozoan Proteins

Identifiers

PMID30317151
PMCPMC6295348

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.