ArticleColloids and surfaces. B, Biointerfaces2019
Incorporation of functionalized carbon nanotubes into hydrophobic drug crystals for enhancing aqueous dissolution.
Article in Colloids and surfaces. B, Biointerfaces, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 35 citations in OpenAlex.
- In vitro evaluation of hyaluronate-functionalized multi-walled carbon nanotubes containing trigonelline for their anti-cancer activity on A2780 ovarian cancer cells.Scientific reports · 2025Article
- Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-Pharmaceutics · 2025Article
- Polymeric Molecular Envelope Technology for Improved Therapeutics Efficacy: A Review.Current medicinal chemistry · 2025Review
- Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs.Life (Basel, Switzerland) · 2023Review
- Synthesis of Microwave Functionalized, Nanostructured Polylactic Co-Glycolic Acid (Nanomaterials (Basel, Switzerland) · 2023Article
- Synthesis of covalent bonding MWCNT-oligoethylene linezolid conjugates and their antibacterial activity against bacterial strains.RSC advances · 2021Article
- Hydrophilic and Functionalized Nanographene Oxide Incorporated Faster Dissolving Megestrol Acetate.Molecules (Basel, Switzerland) · 2021Article
- Antisolvent precipitative immobilization of micro and nanostructured griseofulvin on laboratory cultured diatom frustules for enhanced aqueous dissolution.Colloids and surfaces. B, Biointerfaces · 2020Article
- Direct incorporation of nano graphene oxide (nGO) into hydrophobic drug crystals for enhanced aqueous dissolution.Colloids and surfaces. B, Biointerfaces · 2020Article
- Synthesis of a Porous CACS applied materials & interfaces · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present for the first time the direct incorporation of carboxylated carbon nanotubes (f-CNTs) into hydrophobic drug particles during their formation via anti-solvent precipitation. The approach was tested using two drugs namely antifungal agent Griseofulvin (GF) and antibiotic Sulfamethoxazole (SMZ) that had very different aqueous solubility. It was observed that the f-CNTs dispersed in the water served as nucleating sites for crystallization and were readily incorporated into the drug particles without altering crystal structure or other properties. The results showed that the hydrophilic f-CNTs dramatically enhanced dissolution rate for both drugs, and the time necessary to reach 80% dissolution (t
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.