ArticleJournal of Ayurveda and integrative medicine
Tinospora cordifolia extract prevents cadmium-induced oxidative stress and hepatotoxicity in experimental rats.
Article in Journal of Ayurveda and integrative medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 35 citations in OpenAlex.
- The Effects of a Nursing Program Applying Zinc Oxide Mixed with Petroleum Jelly and Centella Asiatica Mixed with Aloe Vera on Skin Indicators Among Older Patients in Semi-Intensive Care Units: A Pilot Study.Journal of multidisciplinary healthcare · 2025Trial
- Hematotoxicity Induced by Copper Oxide Nanoparticles and the Attenuating Role of Giloy In Vivo.Cureus · 2023Article
- Intervention of Ayurvedic drugJournal of diabetes and metabolic disorders · 2020Article
- Co-exposure to non-toxic levels of cadmium and fluoride induces hepatotoxicity in rats via triggering mitochondrial oxidative damage, apoptosis, and NF-kB pathways.Environmental science and pollution research international · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCadmium (Cd) pollution is of serious concern due to its toxic effects in both humans and animals. The study investigates the protective effect of Tinospora cordifolia stem methanolic extract (TCME) on Cd induced hepatotoxicity. OBJECTIVE(S): The objective of the study was to explore the hepatoprotective effects of T. cordifolia extract. MATERIALS AND
methodsRats were administered orally with Cd (5 mg/kg) and TCME (100 mg/kg) for 28 days. At the end of the treatment period, serum and liver tissues homogenates were subjected to biochemical analysis.
resultsCd treated rats showed increased activities of the serum marker enzymes of liver damage such as AST and ALT along with increased levels of LPO and protein carbonyl content in liver tissues. Cd treatment also leads to decreased activities of endogenous antioxidants (SOD, CAT, GSH, GPx and GST), membrane ATPases (Na
conclusionThe results of the present investigation reveal the hepatoprotective nature of T.cordifolia against Cd induced hepatotoxicity.
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