Evidence map›Paper›PMID 30316681›Full record

ArticleJournal of neuroimmunology2018

Circulating microRNA plasma profile in MuSK+ myasthenia gravis.

Liis Sabre, Jeffrey T Guptill, Melissa Russo, Vern C Juel, Janice M Massey, James F Howard, Lisa D Hobson-Webb, Anna Rostedt Punga

Abstract read
In one paragraph

Article in Journal of neuroimmunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Circulating miRNAs drive personalized medicine based on subgroup classification in myasthenia gravis patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liis SabreDepartment of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden.
Jeffrey T GuptillDepartment of Neurology, Duke University, Durham, USA.
Melissa RussoDepartment of Neurology, Duke University, Durham, USA.
Vern C JuelDepartment of Neurology, Duke University, Durham, USA.
Janice M MasseyDepartment of Neurology, Duke University, Durham, USA.
James F HowardDepartment of Neurology, University of North Carolina - Chapel Hill, Chapel Hill, USA.
Lisa D Hobson-WebbDepartment of Neurology, Duke University, Durham, USA.
Anna Rostedt PungaDepartment of Neuroscience, Clinical Neurophysiology, Uppsala University, Uppsala, Sweden. Electronic address: anna.rostedt.punga@neuro.uu.se.

Funding

Immunological biomarker studies in myasthenia gravisK23NS085049 · NINDS · DUKE UNIVERSITY · PI GUPTILL, JEFFREY T · 2014 to 2018
$924k
NINDS NIH HHS K23 NS085049
6 · The paper itself

Abstract

Muscle-specific tyrosine kinase antibody positive myasthenia gravis (MuSK+ MG) is an immunological subtype with distinctive pathogenic mechanisms and clinical features. The aim of this study was to analyze the circulating plasma microRNA profile of patients with MuSK+ MG. From the discovery cohort miR-210-3p, miR-324-3p and miR-328-3p were further analyzed in the validation cohort. We found a distinct plasma profile of miR-210-3p and miR-324-3p that were significantly decreased in MuSK+ MG patients compared to healthy controls (4.1 ± 1.4 vs 5.1 ± 1.4, p = .006 and 4.7 ± 1.0 vs 5.4 ± 1.3, p = .02). These findings reveal a distinct plasma miRNA profile in MuSK+ MG.

Indexed as

AdultAutoantibodiesCirculating MicroRNACohort StudiesFemaleHumansMaleMiddle AgedMyasthenia GravisReceptor Protein-Tyrosine KinasesReceptors, CholinergicAutoantibodiesCirculating MicroRNAMUSK protein, humanReceptor Protein-Tyrosine KinasesReceptors, CholinergicBiomarkermicroRNAMuscle-specific tyrosine kinaseMuSKMyasthenia gravis

Identifiers

PMID30316681
PMCPMC6240475

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.