ArticleJournal of diabetes and its complications2018
The early natural history of albuminuria in young adults with youth-onset type 1 and type 2 diabetes.
Article in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- ISPAD Clinical Practice Consensus Guidelines 2024: Type 2 Diabetes in Children and Adolescents.Hormone research in paediatrics · 2024Guideline
- Addressing Unmet Needs in the Management of Chronic Kidney Disease.International journal of general medicine · 2026Review
- Prevalence and clinical characteristics of chronic kidney disease among patients with newly diagnosed ketosis-onset diabetes.World journal of diabetes · 2025Article
- Characterizing the relationship between social determinants of health and risk of albuminuria among children with type 1 diabetes.Journal of diabetes and its complications · 2024Article
- Transient albuminuria in the setting of short-term severe hyperglycemia in type 1 diabetes.Journal of diabetes and its complications · 2024Article
- Urine Dipstick Analysis on Automated Platforms: Is a Reliable Screening Tool for Proteinuria? An Experience from Umberto I Hospital in Rome.Biomedicines · 2023Article
- Longitudinal Estimated Glomerular Filtration Rate Trajectories in Children with Type 1 Diabetes.Pediatric diabetes · 2023Article
- Predictors of microalbuminuria and its relationship with glycemic control among Type 2 diabetic patients of Jazan Armed Forces Hospital, southwestern Saudi Arabia.BMC endocrine disorders · 2022Article
- Albuminuria screening in children with type 1 diabetes prior to and during the COVID-19 pandemic.Pediatric research · 2022Article
- Diabetic kidney disease in children and adolescents: an update.Pediatric nephrology (Berlin, Germany) · 2022Review
- Type 2 diabetes in youth: Rationale for use of off-label antidiabetic agents.Pediatric diabetes · 2022Article
- KDOQI US Commentary on the KDIGO 2020 Clinical Practice Guideline for Diabetes Management in CKD.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2022Article
- Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need.The Korean journal of internal medicine · 2021Review
- Youth-onset type 2 diabetes: translating epidemiology into clinical trials.Diabetologia · 2021Review
- Trajectories in estimated glomerular filtration rate in youth-onset type 1 and type 2 diabetes: The SEARCH for Diabetes in Youth Study.Journal of diabetes and its complications · 2021Article
- Type 2 Diabetes in Youth.Global pediatric health · 2020Review
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Authors and funding
15 authors at 9 institutions in 1 country.
Funding
Abstract
aimsTo determine among adolescents and young adults with youth-onset type 1 diabetes and type 2 diabetes the rates and risk factors for albuminuria regression and progression.
methodsData from SEARCH, a longitudinal observational study of youth-onset type 1 diabetes (N = 1316) and type 2 diabetes (N = 143) were analyzed. Urine albumin:creatinine ratio (UACR) was measured from random urine specimens at baseline and follow-up visits (mean 7 years later). Albuminuria regression was defined as halving of baseline UACR when baseline UACR was ≥30 μg/mg; progression was defined as doubling of baseline UACR when follow-up UACR was ≥30 μg/mg, respectively. Multivariable regression assessed risk factors associated with low-risk albuminuria category (combined persistently-low albuminuria and regression) versus moderate-risk albuminuria category (combined persistently-high albuminuria and progression).
resultsAlbuminuria progression was more common in type 2 diabetes versus type 1 diabetes (15.4% versus 6.0%, p<0.001). Moderate-risk albuminuria was associated with increasing HbA1c (adjusted OR (aOR) = 1.3, 95% CI 1.1-1.6) and lack of private health insurance (aOR = 2.7, 95%CI 1.1-6.5) in type 1 diabetes; and African American race (OR = 4.6, 95% CI 1.2-14.2), lower estimated insulin sensitivity score (aOR = 2.1, 95% CI 1.4-3.3), baseline UACR (aOR = 3.2, 95% CI 1.7-5.8), and follow-up estimated glomerular filtration rate (eGFR) (10-unit increase aOR = 1.3, 95% CI 1.0, 1.5) in type 2 diabetes.
conclusionsIn the first decade of diabetes duration, kidney complications in type 2 diabetes are significantly more aggressive than in type 1 diabetes and may be associated with less modifiable risk factors including race, insulin sensitivity, and eGFR. Early interventions may help reduce long-term kidney complications.
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