Evidence map›Paper›PMID 30316298›Full record

ArticleJournal of nanobiotechnology2018

Polymer coated gold-ferric oxide superparamagnetic nanoparticles for theranostic applications.

Muhammad Raisul Abedin, Siddesh Umapathi, Harika Mahendrakar, Tunyaboon Laemthong, Holly Coleman, Denise Muchangi, Santimukul Santra, Manashi Nath, Sutapa Barua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 67 citations in OpenAlex.

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  13. Nanoparticle Systems for Cancer Phototherapy: An Overview.Nanomaterials (Basel, Switzerland) · 2021
    Review
  14. Article
  15. Article
  16. Review
  17. Immune cell engineering: opportunities in lung cancer therapeutics.Drug delivery and translational research · 2020
    Review
  18. Imaging techniques in nanomedical research.European journal of histochemistry : EJH · 2020
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Muhammad Raisul AbedinDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO, 65409-1230, USA.
Siddesh UmapathiDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Harika MahendrakarDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO, 65409-1230, USA.
Tunyaboon LaemthongDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO, 65409-1230, USA.
Holly ColemanDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Denise MuchangiDepartment of Chemistry, Pittsburg State University, Pittsburg, KS, 66762, USA.
Santimukul SantraDepartment of Chemistry, Pittsburg State University, Pittsburg, KS, 66762, USA.
Manashi NathDepartment of Chemistry, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Sutapa BaruaDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, 110 Bertelsmeyer Hall, 1101 N. State Street, Rolla, MO, 65409-1230, USA. baruas@mst.edu.ORCID http://orcid.org/0000-0002-2385-0222
State Street (United States) · USMissouri University of Science and Technology · USPittsburg State University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
American Chemical Society Petroleum Research Fund ACS PRF 56629-UNI7Kansas IDeA Network of Biomedical Research Excellence at Pittsburg State University K-INBRE P20GM103418NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

backgroundEngineered inorganic nanoparticles (NPs) are essential components in the development of nanotechnologies. For applications in nanomedicine, particles need to be functionalized to ensure a good dispersibility in biological fluids. In many cases however, functionalization is not sufficient: the particles become either coated by a corona of serum proteins or precipitate out of the solvent. We show that by changing the coating of magnetic iron oxide NPs using poly-L-lysine (PLL) polymer the colloidal stability of the dispersion is improved in aqueous solutions including water, phosphate buffered saline (PBS), PBS with 10% fetal bovine serum (FBS) and cell culture medium, and the internalization of the NPs toward living mammalian cells is profoundly affected.

methodsA multifunctional magnetic NP is designed to perform a near-infrared (NIR)-responsive remote control photothermal ablation for the treatment of breast cancer. In contrast to the previously reported studies of gold (Au) magnetic (Fe

resultsThe PLL coating increased the colloidal stability and robustness of Au-Fe

Indexed as

Cell DeathCell Line, TumorFerric CompoundsFluorescenceGoldHumansHyperthermia, InducedMagnetite NanoparticlesPhototherapyPolylysinePolymersStatic ElectricityTemperatureTheranostic NanomedicineX-Ray DiffractionFerric Compoundsferric oxideGoldMagnetite NanoparticlesPolylysinePolymersBreast cancerCombination treatmentsGold-superparamagnetic nanoparticlesMagnetic resonance imaging (MRI)Photothermal treatmentPolymer coating

Identifiers

PMID30316298
PMCPMC6186064
OpenAlexW2897138499

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.