Evidence map›Paper›PMID 30316066›Full record

ReviewCurrent opinion in neurobiology2018

Molecular mechanisms underlying sexual differentiation of the nervous system.

Joseph R Knoedler, Nirao M Shah

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Variability in Neural Circuit Formation.Cold Spring Harbor perspectives in biology · 2024
    Review
  8. Article
  9. Prenatal PMEnvironmental research · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. The Role of Transposable Elements in Sexual Development.Frontiers in behavioral neuroscience · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph R KnoedlerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States.
Nirao M ShahDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305, United States; Department of Neurobiology, Stanford University, Stanford, CA 94305, United States. Electronic address: nirao@stanford.edu.

Funding

Characterization of Sexual Dimorphism in the BrainR01NS049488 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nirao Mahesh Shah · 2005 to 2026
$8.7M
Molecular and Neural Networks Underlying Social AttachmentR01MH108319 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BALES, KAREN L., SHAH, NIRAO MAHESH · 2016 to 2020
$3.1M
Dissecting hypothalamic pathways that regulate sexually dimorphic behaviorsR01NS083872 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHAH, NIRAO MAHESH · 2013 to 2017
$1.8M
NIMH NIH HHS R01 MH108319NINDS NIH HHS R01 NS049488NINDS NIH HHS R01 NS083872
6 · The paper itself

Abstract

A long-standing goal in developmental neuroscience is to understand the mechanisms by which steroid sex hormones pattern the mammalian central nervous system along male or female pathways to enable subsequent displays of sexually dimorphic behaviors. In this article, we review recent advances in understanding the epigenetic and transcriptional mechanisms mediating sexual differentiation of the brain in mammals, flies, and worms. These studies suggest a model of sexual differentiation wherein master regulators of sex determination initiate a cascade of sexually dimorphic gene expression that controls development of neural pathways and behavioral displays in a strikingly modular manner. With these advances in molecular genetics, it is now feasible to disassemble different components of sexually dimorphic social behaviors without disrupting other behavioral interactions. Such experimental tractability promises rapid advances in this exciting field.

Indexed as

Social BehaviorAnimalsBehavior, AnimalBrainEpigenesis, GeneticGonadal Steroid HormonesSensory Receptor CellsSex DifferentiationGonadal Steroid Hormones

Identifiers

PMID30316066
PMCPMC6347421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.