ArticleEuropean journal of medicinal chemistry2018
Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane.
Article in European journal of medicinal chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Defining a lipophilicity window for the antimicrobial activity of 7-Alkoxy-3-Amino coumarin amphiphiles.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- SmIAngewandte Chemie (International ed. in English) · 2025Article
- Article
- A comprehensive insight into naphthalimides as novel structural skeleton of multitargeting promising antibiotics.Future medicinal chemistry · 2025Review
- Antimicrobial Peptide Mimics for Clinical Use: Does Size Matter?Frontiers in immunology · 2022Review
- Fluorescence Microscopy-An Outline of Hardware, Biological Handling, and Fluorophore Considerations.Cells · 2021Review
- Naphthalimide-Containing BP100 Leads to Higher Model Membranes Interactions and Antimicrobial Activity.Biomolecules · 2021Article
- Positional Isomers of Biphenyl Antimicrobial Peptidomimetic Amphiphiles.ACS medicinal chemistry letters · 2021Article
- Scaffold diversity for enhanced activity of glycosylated inhibitors of fungal adhesion.RSC medicinal chemistry · 2020Article
- Short Cationic Peptidomimetic Antimicrobials.Antibiotics (Basel, Switzerland) · 2019Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
Abstract
The design, synthesis and evaluation of a small series of potent amphiphilic norbornane antibacterial agents has been performed (compound 10 MIC = 0.25 μg/mL against MRSA). Molecular modelling indicates rapid aggregation of this class of antibacterial agent prior to membrane association and insertion. Two fluorescent analogues (compound 29 with 4-amino-naphthalimide and 34 with 4-nitrobenz-2-oxa-1,3-diazole fluorophores) with good activity (MIC = 0.5 μg/mL against MRSA) were also constructed and confocal microscopy studies indicate that the primary site of interaction for this family of compounds is the bacterial membrane.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.