ArticleNeuroImage2019
Neonate and infant brain development from birth to 2 years assessed using MRI-based quantitative susceptibility mapping.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Quantitative susceptibility mapping in pediatric neuroimaging: a systematic review of applications and advancements.Pediatric radiology · 2026Pooled it
- Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study.Fluids and barriers of the CNS · 2023Trial
- Postnatal maturation of putamen microstructure accompanies topographic white matter connectivity and altered circuits in autism.bioRxiv : the preprint server for biology · 2026Article
- Translational Initiative to Minimize Childhood Hemiparesis After Asymmetrical Perinatal Brain Injury.Bioengineering (Basel, Switzerland) · 2026Article
- Susceptibility Source Separation Unveils Paramagnetic and Diamagnetic Trajectories in Healthy Brains From 5 to 90 Years.NMR in biomedicine · 2026Article
- Importance of RMagnetic resonance in medicine · 2026Article
- Prevalence of respiratory distress syndrome among late preterm infants admitted to a neonatal intensive care unit in Saudi Arabia: A retrospective study.Saudi medical journal · 2025Article
- Rapid, high-resolution and distortion-freeMagnetic resonance in medicine · 2025Article
- 7 Tesla fMRI characterisation of the cortical-depth-dependent BOLD response in early human development.bioRxiv : the preprint server for biology · 2025Article
- Rapid, High-resolution and Distortion-freeArXiv · 2025Article
- Decoding Brain Development and Aging: Pioneering Insights From MRI Techniques.Investigative radiology · 2025Review
- Comparison study of quantitative susceptibility mapping with GRAPPA and wave-CAIPI: reproducibility, consistency, and microbleeds detection.Japanese journal of radiology · 2025Article
- Quantitative Susceptibility Mapping with Source Separation in Normal Brain Development of Newborns.AJNR. American journal of neuroradiology · 2025Article
- Spherical echo-planar time-resolved imaging (sEPTI) for rapid 3D quantitativeMagnetic resonance in medicine · 2025Article
- Mitochondria-derived reactive oxygen species induce over-differentiation of neural stem/progenitor cells after non-cytotoxic cisplatin exposure.Frontiers in cell and developmental biology · 2025Article
- Effect of moderate hyperbilirubinemia on an infant's brain: a quantitative susceptibility mapping andFrontiers in pediatrics · 2025Article
- Identification of neural alterations in patients with Crohn's disease with a novel multiparametric brain MRI-based radiomics model.Insights into imaging · 2024Article
- Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.AJNR. American journal of neuroradiology · 2024Article
- Quantitative susceptibility mapping in the brain reflects spatial expression of genes involved in iron homeostasis and myelination.Human brain mapping · 2024Article
- Association of brain functional connectivity with neurodevelopmental outcomes in healthy full-term newborns.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The human brain rapidly develops during the first two years following birth. Quantitative susceptibility mapping (QSM) provides information of iron and myelin variations. It is considered to be a valuable tool for studying brain development in early life. In the present work, QSM is performed on neonates, 1-year and 2-year old infants, as well as a group of adults for the purpose of reference. Age-specific templates representing common brain structures are built for each age group. The neonate and infant QSM templates have shown some unique findings compared to conventional T1w and T2w imaging techniques. The contrast between the gray and white matters on the QSM images did not change through brain development from neonate to adult. A linear correlation was found between brain myelination determined in this study and the microscopic myelin degree determined by a previous autopsy study. Also, the magnetic susceptibility values of the cerebral spinal fluid (CSF) exhibit a gradually decreasing trend from birth to 2 years old and to adulthood. The findings suggest that the macromolecular content, myelin, and iron may play the most important contributing factors for the magnetic susceptibility of neonate and infant brain. QSM can be a powerful means to study early brain development and related pathologies that involve alterations in macromolecular content, iron, or brain myelination.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.