Evidence map›Paper›PMID 30315870›Full record

ReviewBiotechnology advances2018

Synthetic biology tools for engineering Yarrowia lipolytica.

M Larroude, T Rossignol, J-M Nicaud, R Ledesma-Amaro

Abstract readReview
In one paragraph

Review in Biotechnology advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. In Vivo DNA Assembly inACS synthetic biology · 2025
    Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Metabolic engineering ofFrontiers in bioengineering and biotechnology · 2025
    Article
  11. Frontiers in microbiology · 2025
    Review
  12. Review
  13. Development of genetic markers in Yarrowia lipolytica.Applied microbiology and biotechnology · 2024
    Article
  14. Article
  15. Review
  16. Broadening the application ofMicrobiology (Reading, England) · 2024
    Article
  17. Review
  18. Review
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

M LarroudeMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
T RossignolMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
J-M NicaudMicalis Institute, INRA, AgroParisTech, Université Paris-Saclay, 78350 Jouy-en-Josas, France.
R Ledesma-AmaroDepartment of Bioengineering and Imperial College Centre for Synthetic Biology, Imperial College London, London, United Kingdom. Electronic address: r.ledesma-amaro@imperial.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/R01602X/1
6 · The paper itself

Abstract

The non-conventional oleaginous yeast Yarrowia lipolytica shows great industrial promise. It naturally produces certain compounds of interest but can also artificially generate non-native metabolites, thanks to an engineering process made possible by the significant expansion of a dedicated genetic toolbox. In this review, we present recently developed synthetic biology tools that facilitate the manipulation of Y. lipolytica, including 1) DNA assembly techniques, 2) DNA parts for constructing expression cassettes, 3) genome-editing techniques, and 4) computational tools.

Indexed as

Metabolic EngineeringSynthetic BiologyYarrowiaCRISPR-Cas SystemsGene EditingCRISPR-Cas9DNA assemblyGenome editingGenome scale metabolic modelsGolden GateIndustrial biotechnologyMetabolic engineeringSynthetic biologyYarrowia lipolytica

Identifiers

PMID30315870
PMCPMC6261845

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.