Trial reportSleep & breathing = Schlaf & Atmung2019
Alterations of the brain network in idiopathic rapid eye movement sleep behavior disorder: structural connectivity analysis.
Trial report in Sleep & breathing = Schlaf & Atmung, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The trial behind it
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Who cites it
20 citing papers in PubMed.
- Altered network efficiency in isolated REM sleep behavior disorder: A multicentric study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Altered functional network topology and connectivity in female nurses with shift work sleep disorder.Frontiers in systems neuroscience · 2025Article
- Cuneus atrophy and Parkinsonian phenoconversion in cognitively unimpaired patients with isolated REM sleep behavior disorder.Journal of neurology · 2024Article
- Surface-Based Morphometry Analysis of the Cerebral Cortex in Patients With Probable Idiopathic Rapid Eye Movement Sleep Behavior Disorder.Brain and behavior · 2024Article
- Rapid eye movement sleep behavior disorder and its relation to Parkinson's disease: The potential of graph measures as brain biomarkers to identify the underlying physiopathology of the disorder.Brain and behavior · 2024Review
- Neuroanatomical findings in isolated REM sleep behavior disorder and early Parkinson's disease: a Voxel-based morphometry study.Brain imaging and behavior · 2024Article
- Brain MRI Biomarkers in Isolated Rapid Eye Movement Sleep Behavior Disorder: Where Are We? A Systematic Review.Brain sciences · 2023Review
- Involvement of limbic structures in patients with isolated rapid eye movement sleep behavior disorder.Sleep and biological rhythms · 2023Article
- MRI findings in movement disorders and associated sleep disturbances.American journal of nuclear medicine and molecular imaging · 2023Review
- Application of machine learning analysis based on diffusion tensor imaging to identify REM sleep behavior disorder.Sleep & breathing = Schlaf & Atmung · 2022Article
- Sleep Dysfunction and Grey Matter Volume.Current neurology and neuroscience reports · 2022Review
- Alterations of Regional Homogeneity in Parkinson's Disease with Rapid Eye Movement Sleep Behavior Disorder.Neuropsychiatric disease and treatment · 2022Article
- Impaired Brain Information Transmission Efficiency and Flexibility in Parkinson's Disease and Rapid Eye Movement Sleep Behavior Disorder: Evidence from Functional Connectivity and Functional Dynamics.Parkinson's disease · 2022Article
- Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder.Frontiers in aging neuroscience · 2022Article
- Neurochemical Features of Rem Sleep Behaviour Disorder.Journal of personalized medicine · 2021Review
- Voxel-based correlation ofeNeurologicalSci · 2021Article
- Alteration of brain structural connectivity in progression of Parkinson's disease: A connectome-wide network analysis.NeuroImage. Clinical · 2021Article
- Disruption of posterior brain functional connectivity and its relation to cognitive impairment in idiopathic REM sleep behavior disorder.NeuroImage. Clinical · 2020Article
- Cortical gray matter progression in idiopathic REM sleep behavior disorder and its relation to cognitive decline.NeuroImage. Clinical · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
purposeTo evaluate and compare structural connectivity using graph theoretical analysis in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD) and healthy subjects.
methodsTen consecutive patients with iRBD were recruited from a single tertiary hospital. All patients had normal brain magnetic resonance imaging results on visual inspection. They did not have any other neurological disorder. Control subjects were also enrolled. All subjects underwent three-dimensional volumetric T1-weighted imaging. Absolute structural volumes were calculated using FreeSurfer image analysis software. Structural volume and connectivity analyses were performed with Brain Analysis using Graph Theory.
resultsCompared to healthy controls, patients with iRBD showed significant alterations in cortical and subcortical volumes, showing increased volumes of frontal cortex, thalamus, and caudate nucleus. In addition, patients with iRBD exhibited significantly different structural connectivity compared to healthy controls. In measures of global network, average degree, global efficiency, and local efficiency were decreased whereas characteristic path length was increased in iRBD patients. In measures of local network, there was significant hub reorganization in patients with iRBD. Betweenness centrality of caudate nucleus and frontal cortex was increased in patients with iRBD.
conclusionsThis is the first study to report that structural volume and connectivity in patients with iRBD are significantly different from those in healthy controls. iRBD patients exhibited disrupted topological disorganization of the global brain network and hub reorganization. These alterations are implicated in the pathogenesis of iRBD. They might be potential biomarkers of iRBD.
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