Evidence map›Paper›PMID 30315387›Full record

ArticleCellular and molecular neurobiology2018

PGC-1α-Mediated Mitochondrial Biogenesis is Involved in Cannabinoid Receptor 2 Agonist AM1241-Induced Microglial Phenotype Amelioration.

Lei Ma, Wen Niu, Jianrui Lv, Ji Jia, Miaozhang Zhu, Shuai Yang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

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  19. Cannabinoid CBCellular and molecular neurobiology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lei MaDepartment of Physiology and Pathophysiology, The Fourth Military Medical University, Xi'an, 710032, China.
Wen NiuDepartment of Physiology and Pathophysiology, The Fourth Military Medical University, Xi'an, 710032, China.
Jianrui LvDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Ji JiaDepartment of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, China.
Miaozhang ZhuDepartment of Physiology and Pathophysiology, The Fourth Military Medical University, Xi'an, 710032, China. nm0214@fmmu.edu.cn.ORCID http://orcid.org/0000-0002-8559-3305
Shuai YangDepartment of Neurosurgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, China. ysh_gzh@126.com.
Second Affiliated Hospital of Xi'an Jiaotong University · CNAir Force Medical University · CNSun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81601148National Natural Science Foundation of China 81700058Natural Science Foundation of Shaanxi Province (CN) 2018JM7087
6 · The paper itself

Abstract

Cannabinoid type 2 receptor (CB2R) agonist AM1241 induces anti-inflammation by ameliorating microglial phenotypes, the mechanism, however, is still unknown. Peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α) is a transcription protein which can regulate mitochondrial biogenesis, and the aim of this study is to investigate whether PGC-1α is involved in AM1241-induced anti-inflammation in N9 microglial cells. We used 10 ng/ml lipopolysaccharide (LPS) plus 10 U/ml interferon γ (IFNγ) to activate microglia into classic activated phenotype (M1 phenotype), and found that co-administration of 10 µM AM1241 increased the expressions of mitochondria biogenesis-associated proteins, including nuclear respiratory factor 1 (NRF-1), mitochondrial transcription factor A (TFAM) and COX IV, and up-regulated the biomarker levels of microglial M2 phenotype, including arginase 1 (Arg-1) and brain-derived neurotrophic factor (BDNF), and down-regulated biomarker levels of M1 phenotype, including inducible nitric oxide synthase (iNOS) and tumor necrosis factor α (TNF-α), compared to the cells treated with LPS plus IFNγ only (P < 0.05). By using PGC-1α-siRNA, however, we found that down-regulation of PGC-1α significantly reversed the AM1241-induced effects above (P < 0.05). According to the results in this study, we found that PGC-1α may mediate CB2R agonist AM1241-induced anti-inflammation in N9 microglial cells, and the mechanism might be associated with the enhancement of mitochondria biogenesis.

Indexed as

Organelle BiogenesisAnimalsCannabinoidsCell LineEnergy MetabolismMicrogliaMitochondriaPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhenotypeRatsReceptor, Cannabinoid, CB2RNA, Small InterferingAM 1241CannabinoidsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseReceptor, Cannabinoid, CB2RNA, Small InterferingCannabinoid type 2 receptorInflammationMicrogliaMitochondrial biogenesisPGC-1α

Identifiers

PMID30315387
PMCPMC11469869
OpenAlexW2898007487

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.