Evidence map›Paper›PMID 30315323›Full record

ArticleCurrent microbiology2019

cAMP Receptor Protein of Salmonella enterica Serovar Typhimurium Modulate Glycolysis in Macrophages to Induce Cell Apoptosis.

Ke Ding, Chunjie Zhang, Jing Li, Songbiao Chen, Chengshui Liao, Xiangchao Cheng, Chuang Yu, Zuhua Yu, Yanyan Jia

Abstract read
PubMed Publisher
In one paragraph

Article in Current microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

  1. Microbiota in cancer: current understandings and future perspectives.Signal transduction and targeted therapy · 2026
    Review
  2. How Bacterial Pathogens Coordinate Appetite with Virulence.Microbiology and molecular biology reviews : MMBR · 2023
    Review
  3. Study the Ability ofArchives of Razi Institute · 2022
    Article
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ke DingThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Chunjie ZhangThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China. cjzhang@sina.com.
Jing LiThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Songbiao ChenThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Chengshui LiaoThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Xiangchao ChengThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Chuang YuThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Zuhua YuThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Yanyan JiaThe Key Lab of Animal Disease and Public Healthy, Henan University of Science and Technology, Luoyang, China.
Henan University of Science and Technology · CNLuoyang Institute of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the role of glycolysis in the mechanism of cAMP receptor protein-induced macrophage cell death of Salmonella enterica serovar Typhimurium (S. Typhimurium). Cell apoptosis, caspase-3, -8, -9 enzyme activity, and pyruvic acid, lactic acid, ATP, and hexokinase (HK) contents were determined after infection of macrophages with S. Typhimurium SL1344 wild-type and a cAMP receptor protein mutant strain. While cell apoptosis, caspase-3, -8, -9 enzyme activity, lactic acid, hexokinase, and ATP levels significantly changed by infection with crp mutants compared to the wild-type strain (P < 0.05). Our data suggest that the cAMP receptor protein of S. Typhimurium can modulate macrophage death by effecting glycolysis levels. This finding may help to elucidate the mechanisms of S. Typhimurium pathogenesis.

Indexed as

Adenosine TriphosphateAnimalsApoptosisCaspase 3Caspase 8Caspase 9Cell LineCyclic AMP Receptor ProteinGlycolysisHexokinaseLactic AcidMacrophagesMicePyruvic AcidRAW 264.7 CellsSalmonella typhimuriumAdenosine TriphosphateCaspase 3Caspase 8Caspase 9Cyclic AMP Receptor ProteinHexokinaseLactic AcidPyruvic Acid

Identifiers

PMID30315323
OpenAlexW2895888193

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.