Evidence map›Paper›PMID 30315237›Full record

ArticleLeukemia2019

Preclinical assessment of an antibody-PBD conjugate that targets BCMA on multiple myeloma and myeloma progenitor cells.

Krista Kinneer, Matt Flynn, Suneetha B Thomas, John Meekin, Reena Varkey, Xiaodong Xiao, Haihong Zhong, Shannon Breen, Paul G Hynes, Ryan Fleming and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  12. Targeting BCMA in Multiple Myeloma.Current hematologic malignancy reports · 2021
    Review
  13. BCMA-Specific ADC MEDI2228 and Daratumumab Induce Synergistic Myeloma Cytotoxicity via IFN-Driven Immune Responses and Enhanced CD38 Expression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Krista KinneerMedImmune, Oncology Research, Gaithersburg, MD, USA. kinneerk@medimmune.com.
Matt FlynnMedImmune, Oncology Research, Gaithersburg, MD, USA.
Suneetha B ThomasMedImmune, Oncology Research, Gaithersburg, MD, USA.
John MeekinMedImmune, Oncology Research, Gaithersburg, MD, USA.
Reena VarkeyMedImmune, Antibody Discovery and Protein Engineering, Gaithersburg, MD, USA.
Xiaodong XiaoMedImmune, Antibody Discovery and Protein Engineering, Gaithersburg, MD, USA.
Haihong ZhongMedImmune, Oncology Research, Gaithersburg, MD, USA.
Shannon BreenMedImmune, Oncology Research, Gaithersburg, MD, USA.
Paul G HynesMedImmune, Oncology Research, Gaithersburg, MD, USA.
Ryan FlemingMedImmune, Antibody Discovery and Protein Engineering, Gaithersburg, MD, USA.
Binyam BezabehMedImmune, Antibody Discovery and Protein Engineering, Gaithersburg, MD, USA.
Cui Tracy ChenMedImmune, Oncology Research, Gaithersburg, MD, USA.
Leslie WetzelMedImmune, Oncology Research, Gaithersburg, MD, USA.
Ruoyan ChenMedImmune, Biosuperiors, Gaithersburg, MD, USA.
Nazzareno DimasiMedImmune, Antibody Discovery and Protein Engineering, Gaithersburg, MD, USA.ORCID http://orcid.org/0000-0001-9379-1646
Yu-Tzu TaiDana-Farber Cancer Institute, Boston, MA, USA.
Kenneth C AndersonDana-Farber Cancer Institute, Boston, MA, USA.
Ronald HerbstMedImmune, Oncology Research, Gaithersburg, MD, USA.
Philip W HowardSpirogen, London, UK.
Elaine M HurtMedImmune, Oncology Research, Gaithersburg, MD, USA.
David A TiceMedImmune, Oncology Research, Gaithersburg, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AntibodiesB-Cell Maturation AntigenBenzodiazepinesDrug Evaluation, PreclinicalHumansMultiple MyelomaPyrrolesStem CellsAntibodiesB-Cell Maturation AntigenBenzodiazepinesPyrrolespyrrolo(2,1-c)(1,4)benzodiazepine

Identifiers

PMID30315237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.