ArticleNature communications2018
Fine-tuning the efficiency of para-hydrogen-induced hyperpolarization by rational N-heterocyclic carbene design.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed.
- Machine learning-assisted molecular design for efficientChemical science · 2026Article
- Mixture Analysis at Micromolar Concentrations with 2D Benchtop NMR Enhanced by SABRE Hyperpolarization.Analytical chemistry · 2026Article
- AutomatedAnalytical chemistry · 2026Article
- Mechanistic insights into chemical exchange during the signal amplification by reversible exchange sensitization of pyruvate.Nature communications · 2026Article
- Label-Free Measurement of Ligand Interactions Using SABRE Hyperpolarization at Low Magnetic Fields.Analytical chemistry · 2026Article
- SABRE Ir-IMes Catalysis for the Masses.Molecules (Basel, Switzerland) · 2025Article
- Scalable Hyperpolarized MRI Enabled by Ace-SABRE of [1-Angewandte Chemie (International ed. in English) · 2025Article
- Molecular Fragmentation as a Strategy to Access Hyperpolarized Compounds from Para-Hydrogen.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- Base-Promoted Iridium-Catalyzed Deuteration and C-H Bond Activation ofThe Journal of organic chemistry · 2025Article
- Quo Vadis HyperpolarizedZeitschrift fur medizinische Physik · 2025Review
- High HThe journal of physical chemistry letters · 2025Article
- Iridium trihydride and tetrahydride complexes and their role in catalytic polarisation transfer fromChemical science · 2025Article
- Homogeneous Catalysts for Hydrogenative PHIP Used in Biomedical Applications.Analysis & sensing · 2025Article
- Analysis of chemical exchange in iridium N-heterocyclic carbene complexes using heteronuclear parahydrogen-enhanced NMR.Communications chemistry · 2024Article
- Metal complexes of backbone-halogenated imidazol-2-ylidenes.Inorganica chimica acta · 2024Article
- Article
- Metal-Mediated Catalytic Polarization Transfer fromACS catalysis · 2024Article
- Water-Compatible and Recyclable Heterogeneous SABRE Catalyst for NMR Signal Amplification.JACS Au · 2023Article
- Enhancing the NMR signals of plant oil components using hyperpolarisation relayedChemical science · 2023Article
- Benzoquinone Enhances Hyperpolarization of Surface Alcohols with Para-Hydrogen.Journal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Iridium N-heterocyclic carbene (NHC) complexes catalyse the para-hydrogen-induced hyperpolarization process, Signal Amplification by Reversible Exchange (SABRE). This process transfers the latent magnetism of para-hydrogen into a substrate, without changing its chemical identity, to dramatically improve its nuclear magnetic resonance (NMR) detectability. By synthesizing and examining over 30 NHC containing complexes, here we rationalize the key characteristics of efficient SABRE catalysis prior to using appropriate catalyst-substrate combinations to quantify the substrate's NMR detectability. These optimizations deliver polarizations of 63% for
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Registered trials
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