ArticleMedical science monitor : international medical journal of experimental and clinical research2018
Expression of B7 Homolog 1 (B7H1) Is Associated with Clinicopathologic Features in Urothelial Bladder Cancer.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Prognostic and Clinicopathological Significance of PD-L1 in Patients With Bladder Cancer: A Meta-Analysis.Frontiers in pharmacology · 2019Pooled it
- Immunoexpression of PD-L1 and PD-1 and Its Clinicopathological Correlation in Urothelial Carcinomas.Journal of laboratory physicians · 2022Article
- Diagnostic Utility of Serum Golgi Phosphoprotein 3 in Bladder Cancer Patients.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND B7 homolog 1 (B7H1) plays an important role in regulating tumor immunity. The purpose of this study was to probe the relationship between B7H1 expression and clinical outcomes in urothelial bladder cancer. MATERIAL AND METHODS We investigated 110 urothelial bladder cancer cases. The expressions of B7H1 in tumors were analyzed by immunohistochemistry and RT-PCR. The correlation between B7H1 expression and survival rate was analyzed by log-rank test. RESULTS B7H1 expression was significantly increased in cancerous tissues compared to normal tissues (p<0.05). B7H1 expression was not associated with sex, age, diameter, or the combination of these factors (p>0.05). The positive expression of B7-H1 was positively correlated with grade, stage, recurrence, and metastasis (p<0.05). The RT-PCR results were consistent with the immunohistochemistry outcomes. Furthermore, the expression of B7H1 in tumors was highly correlated with the survival rate (p<0.05). CONCLUSIONS Expression of B7H1 is correlated with clinicopathologic features in bladder cancer. Up-regulation of B7H1 can result in progression and recurrence of urothelial bladder cancer.
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