Evidence map›Paper›PMID 30315114›Full record

ArticleCancer research2019

Deletion of

Jordan A Torok, Patrick Oh, Katherine D Castle, Michael Reinsvold, Yan Ma, Lixia Luo, Chang-Lung Lee, David G Kirsch

Abstract read
In one paragraph

Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jordan A Torok *Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Patrick Oh *Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Katherine D CastleDepartment of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina.
Michael ReinsvoldDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Yan MaDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Lixia LuoDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
Chang-Lung LeeDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina.
David G KirschDepartment of Radiation Oncology, Duke University Medical Center, Durham, North Carolina david.kirsch@duke.edu.
Duke Medical Center · US

Funding

Advancing Cancer Therapy through Ground Breaking Research in Radiation BiologyR35CA197616 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI David Guy Kirsch · 2016 to 2026
$10.7M
Radiation Therapy: Dissecting the Role of Stromal Cells in Tumor ControlR01CA169220 · NCI · DUKE UNIVERSITY · PI KIRSCH, DAVID GUY · 2013 to 2015
$1.3M
NCI NIH HHS R01 CA169220NCI NIH HHS R35 CA197616
6 · The paper itself

Abstract

Stereotactic body radiotherapy is utilized to treat lung cancer. The mechanism of tumor response to high-dose radiotherapy (HDRT) is controversial, with competing hypotheses of increased direct tumor cell killing versus indirect effects on stroma including endothelial cells. Here we used dual recombinase technology in a primary murine lung cancer model to test whether tumor cells or endothelial cells are critical HDRT targets. Lenti-Cre deleted one or two copies of ataxia-telangiectasia mutated gene (

Indexed as

Disease Models, AnimalRadiation ToleranceAdenocarcinoma of LungAnimalsApoptosisAtaxia Telangiectasia Mutated ProteinsCell ProliferationEndothelial CellsLung NeoplasmsMiceMice, KnockoutSequence DeletionTumor Cells, CulturedAtaxia Telangiectasia Mutated ProteinsAtm protein, mouse

Identifiers

PMID30315114
PMCPMC6377832
OpenAlexW2897669680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.