Evidence map›Paper›PMID 30315106›Full record

ArticleThe Journal of biological chemistry2018

The mucinous domain of pancreatic carboxyl-ester lipase (CEL) contains core 1/core 2

Khadija El Jellas, Bente B Johansson, Karianne Fjeld, Aristotelis Antonopoulos, Heike Immervoll, Man H Choi, Dag Hoem, Mark E Lowe, Dominique Lombardo, Pål R Njølstad and 4 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. The genetic risk factor CEL-HYB1 causes proteotoxicity and chronic pancreatitis in mice.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 4 countries.

Khadija El JellasFrom the Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway.
Bente B JohanssonKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
Karianne FjeldKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
Aristotelis AntonopoulosDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.ORCID 0000-0002-1592-4092
Heike ImmervollFrom the Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway.
Man H ChoiFrom the Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway.
Dag HoemDepartment of Gastrointestinal Surgery, Haukeland University Hospital, N-5021 Bergen, Norway.
Mark E LoweDepartment of Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, and.
Dominique LombardoINSERM, CRO2, Center for Research in Biological Oncology and Oncopharmacology, Aix-Marseille University, 13284 Marseille Cedex 07, France.
Pål R NjølstadKG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, N-5020 Bergen, Norway.
Anne DellDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.
Eric MasINSERM, CRO2, Center for Research in Biological Oncology and Oncopharmacology, Aix-Marseille University, 13284 Marseille Cedex 07, France.
Stuart M HaslamDepartment of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, United Kingdom.ORCID 0000-0002-5563-679X
Anders MolvenFrom the Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen, N-5020 Bergen, Norway, anders.molven@uib.no.ORCID 0000-0003-1847-3079
Haukeland University Hospital · NOImperial College London · GBInserm · FRÅlesund Hospital · NOWashington University in St. Louis · US

Funding

Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
Protein-Glycan Interaction Resource of the CFGR24GM098791 · NIGMS · EMORY UNIVERSITY · PI CUMMINGS, RICHARD D, PAULSON, JAMES C · 2011 to 2013
$2.6M
Proteotoxicity in the Pathophysiology of Chronic PancreatitisR01DK097241 · NIDDK · WASHINGTON UNIVERSITY · PI LOWE, MARK E. · 2014 to 2016
$999k
Biotechnology and Biological Sciences Research Council BB/K016164/1NIDDK NIH HHS R01 DK097241NIDDK NIH HHS U01 DK108334NIGMS NIH HHS R24 GM098791
6 · The paper itself

Abstract

Carboxyl-ester lipase (CEL) is a pancreatic fat-digesting enzyme associated with human disease. Rare mutations in the

Indexed as

ABO Blood-Group SystemCarboxylesteraseCell Line, TumorGene Expression Regulation, EnzymologicHumansPancreasPolysaccharidesProtein DomainsABO Blood-Group SystemCarboxylesterasePolysaccharidesABO blood groupBSDLcarboxyl-ester lipaseCELglycomicsglycoproteinimmunohistochemistrylipaseO-glycanspancreaspancreatic cancerpathologyTn antigen

Identifiers

PMID30315106
PMCPMC6302156
OpenAlexW2896882268

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.