ArticleNeurology2018
Risk factors of hippocampal sclerosis in the oldest old: The 90+ Study.
Article in Neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Integrating home-based video teleneuropsychology into neurology clinical practice: Utility in patients with suspected typical or atypical Alzheimer's disease presentations.The Clinical neuropsychologist · 2025Trial
- Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- A novel histological staging of hippocampal sclerosis that is evident in gray matter loss in vivo.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of vascular and degenerative brain pathologies and past medical history from the National Alzheimer's Coordinating Center Database.Journal of neuropathology and experimental neurology · 2023Article
- Hippocampal sclerosis of aging at post-mortem is evident on MRI more than a decade prior.bioRxiv : the preprint server for biology · 2023Article
- Impact and Risk Factors of Limbic Predominant Age-Related TDP-43 Encephalopathy Neuropathologic Change in an Oldest-Old Cohort.Neurology · 2023Article
- Thyroid function and epilepsy: a two-sample Mendelian randomization study.Frontiers in human neuroscience · 2023Article
- "Benign" temporal lobe epilepsy with hippocampal sclerosis: A forgotten entity?Epilepsy & behavior reports · 2020Article
- Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy.Laboratory investigation; a journal of technical methods and pathology · 2019Review
- Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report.Brain : a journal of neurology · 2019Article
- The association of vascular disorders with incident dementia in different age groups.Alzheimer's research & therapy · 2019Article
- TDP-43 proteinopathy in aging: Associations with risk-associated gene variants and with brain parenchymal thyroid hormone levels.Neurobiology of disease · 2019Article
- Predictors of Dementia in the Oldest Old: A Novel Machine Learning Approach.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the risk factors and comorbidities of hippocampal sclerosis (HS) in the oldest-old.
methodsA total of 134 participants with dementia from The 90+ Study with longitudinal evaluations and autopsy were included in this investigation. Participants were divided into 2 groups, one with and one without HS pathology, and differences in clinical and pathologic characteristics were compared.
resultsPersons with HS tended to have a longer duration of dementia compared to participants without HS (mean 4.0 years vs 6.7 years, odds ratio [OR] 1.26; 95% confidence interval [CI] 1.11-1.42;
conclusionWe identified autoimmune conditions (rheumatoid arthritis and thyroid disease) as potential risk factors for HS in our cohort. LBD was the only pathology that was associated with increased odds of HS and those harboring HS pathology had a longer duration of dementia. This suggests multiple pathways of HS pathology among the oldest-old.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.