ArticleEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society2019
Atypical language representation is unfavorable for language abilities following childhood stroke.
Article in European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Implications of age at lesion onset for neuropsychological outcomes: A systematic review focusing on focal brain lesions.Cortex; a journal devoted to the study of the nervous system and behavior · 2023Pooled it
- Spatio-Temporal Signatures of Cognitive Function After Pediatric Arterial Ischemic Stroke-A Pilot Study.Human brain mapping · 2025Article
- Building support for children and families affected by stroke (BUILD CARE): Study protocol.PloS one · 2025Article
- Larger corpus callosum volume is favorable for theory of mind development in healthy children.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Fetal temporal sulcus depth asymmetry has prognostic value for language development.Communications biology · 2023Article
- Childhood stroke.Nature reviews. Disease primers · 2022Review
- The resilience of the developing reading system: multi-modal evidence of incident and recovery after a pediatric stroke.Neurocase · 2021Article
- Effect of corpus callosum agenesis on the language network in children and adolescents.Brain structure & function · 2021Article
- Influence of socioeconomic status on cognitive outcome after childhood arterial ischemic stroke.Developmental medicine and child neurology · 2021Article
- The role of the corpus callosum in language network connectivity in children.Developmental science · 2021Article
- Absence of neural speech discrimination in preterm infants at term-equivalent age.Developmental cognitive neuroscience · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Brain plasticity has often been quoted as a reason for the more favorable outcome in childhood stroke compared to adult stroke. We investigated the relationship between language abilities and language localization in childhood stroke. Seventeen children and adolescents with left- or right-sided ischemic stroke and 18 healthy controls were tested with a comprehensive neurolinguistic test battery, and the individual neural representation of language was measured with an fMRI language paradigm. Overall, 12 of 17 stroke patients showed language abilities below average, and five patients exhibited impaired language performance. fMRI revealed increased activity in right hemisphere areas homotopic to left hemisphere language regions. In sum, seven stroke patients revealed atypical, i.e. bilateral or right lateralized language representation. Typical left hemispheric language lateralization was associated with better performance in naming and word fluency, whereas increased involvement of right homologues was accompanied by worse language outcome. In contrast, lesion lateralization or lesion volume did not correlate with language outcome or atypical language lateralization. Thus, atypical language lateralization is unfavorable for language outcome, and right homologues do not have the same cognitive capacity, even in young children.
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Registered trials
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