ArticleImmunity2018
Distinct Effector B Cells Induced by Unregulated Toll-like Receptor 7 Contribute to Pathogenic Responses in Systemic Lupus Erythematosus.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 674 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
674citing papers in PubMed, 1 pooled it
30.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
674 citing papers in PubMed, 1 synthesis or guideline pooled it, 1,029 citations in OpenAlex.
- Organ-based characterization of B cells in patients with systemic lupus erythematosus.Frontiers in immunology · 2025Pooled it
- CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial.Nature medicine · 2026Trial
- Long-term safety and efficacy of the combination of belimumab and rituximab in the treatment of severe and refractory SLE: a preliminary report.Lupus science & medicine · 2025Trial
- B cells and humoral immunity in melanoma: regulatory and autoimmune-like features and implications for immunotherapy.Oncoimmunology · 2026Review
- The case for an Epstein-Barr virus vaccine: Lessons from its link to systemic lupus erythematosus.Human vaccines & immunotherapeutics · 2026Review
- Identification of a systemic lupus erythematosus disease signature in resting naive B cells.The Journal of clinical investigation · 2026Article
- A distinct effector B cell population drives autoantibody production in SARS-CoV-2 infection.Immunity · 2026Article
- Double-negative B cells mediate the causal association between rheumatoid arthritis and interstitial lung disease: a two-step Mendelian randomization mediation study.Clinical rheumatology · 2026Article
- Expression patterns of CD24 and CD27 resolve the origins and gradual differentiation of CD11cThe EMBO journal · 2026Article
- Viral subversion of B-cell tolerance: mechanisms linking infection to autoimmunity.EMBO reports · 2026Review
- B-cell landscape remodelling following dual BAFF/APRIL inhibition with telitacicept in lupus nephritis: extrafollicular axis clearance and its association with clinical response.Lupus science & medicine · 2026Article
- From Marginal to Central: Marginal Zone-like B Cells as Critical Targets in Cladribine-Treated Multiple Sclerosis.Annals of neurology · 2026Article
- Disease modification in lupus nephritis: towards a pathophysiology-based treatment paradigm.Nature reviews. Nephrology · 2026Review
- Article
- Age-associated B cells predict coronary events in humans and aggravate murine atherosclerosis.Cardiovascular research · 2026Article
- A two-step model of age-associated autoreactivity: B cell-intrinsic aging meets inflammaging.GeroScience · 2026Review
- EBV reactivation priming of the peripheral immune system in multiple sclerosis relapse.Nature medicine · 2026Article
- The SLC15A4-TASL complex is essential for lupus development in mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A homozygous CTLA-4 variant causes CTLA-4 deficiency with severe immune dysregulation.Journal of human immunity · 2026Article
- Human Peripheral B Cell Subsets: Evolving notions about B cell biology and the broad relevance of B cells in disease.Immunological reviews · 2026Review
614 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
23 authors at 5 institutions in 1 country.
Scott A JenksDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Kevin S CashmanDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Esther ZumaqueroDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Urko M MarigortaCenter for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA.
Aakash V PatelDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Xiaoqian WangDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Deepak TomarDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Matthew C WoodruffDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Zoe SimonDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Regina BugrovskyDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Emily L BlalockDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Christopher D ScharerDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Christopher M TiptonDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Chungwen WeiDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
S Sam LimDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA.
Michelle PetriHopkins Lupus Center, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Timothy B NiewoldColton Center for Autoimmunity, NYU School of Medicine, New York, NY, USA.
Jennifer H AnolikDivision of Allergy, Immunology and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA.
Greg GibsonCenter for Integrative Genomics, Georgia Institute of Technology, Atlanta, GA, USA.
F Eun-Hyung LeeDivision of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA, USA.
Jeremy M BossDepartment of Microbiology and Immunology, Emory University, Atlanta, GA, USA.
Frances E LundDepartment of Microbiology, The University of Alabama at Birmingham, Birmingham, AL, USA.
Ignacio SanzDepartment of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University, Atlanta, GA, USA. Electronic address: ignacio.sanz@emory.edu.
Emory University · USGeorgia Institute of Technology · USUniversity of Alabama at Birmingham · USJohns Hopkins University · USUniversity of Rochester Medical Center · US
Funding
Regulation of B cell Responses in SLE and Other Autoimmune DiseasesU19AI110483 · NIAID · EMORY UNIVERSITY · PI JEREMY M. BOSS · 2014 to 2026
$76.6MRegulation of Pathogenic Plasma Cells in Human SLEP01AI125180 · NIAID · EMORY UNIVERSITY · PI Ignacio E. Sanz · 2016 to 2026
$28.2MVirus-induced Cell Fate Decisions in Anti-Viral ImmunityU19AI109962 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEE, FRANCES EUN-HYUNG · 2014 to 2018
$11.6MRole of B Cells in Synovial Inflammation & LN Remodeling in RA ArthritisP01AI078907 · NIAID · UNIVERSITY OF ROCHESTER · PI WU, HULIN · 2010 to 2014
$10.8MProject-004U54CA260563 · NCI · EMORY UNIVERSITY · PI DHODAPKAR, MADHAV V, SANZ, IGNACIO E. · 2020 to 2024
$10.2MA Model System for the Study of Human B-cell ToleranceR37AI049660 · NIAID · UNIVERSITY OF ROCHESTER · PI SANZ, IGNACIO E. · 2010 to 2019
$3.7MNephrology Institutional Training Grant FLSA SupplementT32DK007656 · NIDDK · EMORY UNIVERSITY · PI SANDS, JEFF M, WALL, SUSAN MARIE · 1990 to 2020
$3.5MHopkins Lupus CohortR01AR069572 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI PETRI, MICHELLE A · 2016 to 2020
$3.4MUnderstanding Survival of Human Bone Marrow Long-Lived Plasma CellsR01AI121252 · NIAID · EMORY UNIVERSITY · PI LEE, FRANCES EUN-HYUNG · 2016 to 2020
$2.7MControl of B cell differentiation by IFNg induced transcription factorsR01AI110508 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LUND, FRANCES E. · 2014 to 2024
$2.5MEpigenetic Regulation of Plasma Cells DifferentiationR01AI123733 · NIAID · EMORY UNIVERSITY · PI BOSS, JEREMY M. · 2016 to 2020
$1.9MNCI NIH HHS U54 CA260563NIAID NIH HHS P01 AI078907NIAID NIH HHS P01 AI125180NIAID NIH HHS R01 AI110508NIAID NIH HHS R01 AI121252NIAID NIH HHS R01 AI123733NIAID NIH HHS R37 AI049660NIAID NIH HHS U19 AI109962NIAID NIH HHS U19 AI110483NIAMS NIH HHS R01 AR069572NIDDK NIH HHS T32 DK007656
Abstract
Systemic Lupus Erythematosus (SLE) is characterized by B cells lacking IgD and CD27 (double negative; DN). We show that DN cell expansions reflected a subset of CXCR5
Indexed as
AdultAgedAged, 80 and overB-LymphocytesB-Lymphocyte SubsetsFemaleGene Regulatory NetworksHumansLupus Erythematosus, SystemicMaleMiddle AgedPlasma CellsToll-Like Receptor 7TranscriptomeYoung AdultToll-Like Receptor 7AutoimmunityCD11ceffectorhuman B cellsplasma cellsSystemic Lupus ErythematousT-betToll-like receptor 7TRAF5
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.