ReviewJournal of cataract and refractive surgery2018
Transepithelial versus epithelium-off corneal crosslinking for corneal ectasia.
Review in Journal of cataract and refractive surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Epithelium-on versus epithelium-off corneal collagen crosslinking for keratoconus: a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Pooled it
- Transepithelial Versus Epithelium-Off Corneal Crosslinking for Progressive Keratoconus: Findings From a Cochrane Systematic Review.American journal of ophthalmology · 2021Pooled it
- Transepithelial versus epithelium-off corneal crosslinking for progressive keratoconus.The Cochrane database of systematic reviews · 2021Pooled it
- The efficiency and safety of oxygen-supplemented accelerated transepithelial corneal cross-linking.International ophthalmology · 2021Trial
- Transepithelial corneal cross-linking: a review.International ophthalmology · 2026Review
- Corneal Cross-Linking in Keratoconus: Comparative Analysis of Standard, Accelerated and Transepithelial Protocols.Journal of clinical medicine · 2026Review
- Riboflavin-UV crosslinking of the cornea: Wound healing and biomechanics.Experimental eye research · 2025Review
- A Review of Keratoconus Cross-Linking Treatment Methods.Journal of clinical medicine · 2025Review
- Outcomes of Collagen Crosslinking in Patients with Keratoconus and Co-Existent Limbal Stem Cell Deficiency.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Injectable platelet-rich fibrin for corneal epithelium healing: An in vivo confocal microscopy study after crosslinking.Arquivos brasileiros de oftalmologia · 2025Article
- Efficacy and Safety of Epi-On vs Epi-Off Corneal Cross-Linking in Corneal Ectasia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Clinical ophthalmology (Auckland, N.Z.) · 2025Review
- In Vivo Femtosecond Laser Machined Transepithelial Nonlinear Optical Corneal Crosslinking Compared to Ultraviolet Corneal Crosslinking.Translational vision science & technology · 2024Article
- Prediction model for treatment outcomes 3 years after corneal cross-linking for keratoconus.International ophthalmology · 2024Article
- The effect of transepithelial corneal collagen cross-linking treatment on optical quality of the cornea in keratoconus: 12-month clinical results.International ophthalmology · 2024Article
- Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK: a case series.International journal of ophthalmology · 2024Article
- Dexpanthenol/sodium hyaluronate eye drops for corneal epithelial healing following corneal cross-linking in patients with keratoconus.International ophthalmology · 2023Article
- A review of the epithelial and stromal effects of corneal collagen crosslinking.The ocular surface · 2023Review
- Current clinical practice in corneal crosslinking for treatment of progressive keratoconus in four Nordic countries.Acta ophthalmologica · 2023Article
- Norepinephrine as an Enhancer Promoting Corneal Penetration of Riboflavin for Transepithelial Corneal Crosslinking.Translational vision science & technology · 2023Article
- Novel Technique to Improve the Efficacy of Corneal Cross Linking in Cases of Post LASIK Ectasia.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
This review compared the clinical results of transepithelial corneal crosslinking (CXL) to epithelium-off (epi-off) CXL in progressive corneal ectasia using a metaanalysis. The Cochrane databases and Medline were searched for randomized controlled trials (RCTs). Seven RCTs involving 505 eyes that met the eligibility criteria were identified. The epi-off CXL group showed significantly better outcomes in postoperative changes in maximum keratometry (K) during 1-year observation periods. Transepithelial CXL resulted in significantly greater post-treatment central corneal thickness and best spectacle-corrected visual acuity (BSCVA). The presence of a postoperative demarcation line was significantly more frequent after epi-off CXL than that after transepithelial CXL. No statistically significant difference was found between other parameters. Although patients in the transepithelial CXL group demonstrated a greater improvement in BSCVA compared with patients in the epi-off CXL group at the 1 year follow-up, transepithelial CXL had less impact on halting progressive corneal ectasia in terms of maximum K than epi-off CXL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.