Evidence map›Paper›PMID 30314660›Full record

ArticleThe Journal of pediatrics2018

Multiple Endocrine Neoplasia Type 2B Presents Early in Childhood but Often Is Undiagnosed for Years.

Angeliki Makri, Srivandana Akshintala, Claudia Derse-Anthony, Brigitte Widemann, Constantine A Stratakis, John Glod, Maya Lodish

Abstract read
In one paragraph

Article in The Journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
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  4. Article
  5. Fracture Risk in Pediatric Patients With MEN2B.The Journal of clinical endocrinology and metabolism · 2022
    Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Angeliki MakriEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD. Electronic address: angeliki.makri@nih.gov.
Srivandana AkshintalaPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD; Division of Pediatric Hematology/Oncology, New York University School of Medicine, New York, NY.
Claudia Derse-AnthonyClinical Research Directorate/Clinical Monitoring Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD.
Brigitte WidemannPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Constantine A StratakisEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD.
John GlodPediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Maya LodishEunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, MD.
National Institutes of Health · USLeidos (United States) · US

Funding

Pediatric Oncology Branch Clinical Care and EducationZIEBC011516 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI GLOD, JOHN · 2013 to 2025
$69.1M
Molecular Genetics of Endocrine Tumors and Related DisordersZIAHD008920 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI STRATAKIS, CONSTANTINE A. · 2012 to 2021
$25.8M
Pediatric Endocrinology Training ProgramZIEHD008944 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2014 to 2025
$12.1M
CCR NIH HHS HHSN261200800001CIntramural NIH HHS Z99 CA999999NCI NIH HHS HHSN261200800001E
6 · The paper itself

Abstract

We describe the presenting symptoms and signs of multiple endocrine neoplasia type 2B in a cohort of children. Improved awareness of the early nonendocrine signs of multiple endocrine neoplasia type 2B could lead to earlier diagnosis before the development of medullary thyroid cancer and possibly its metastasis.

Indexed as

AdolescentAdrenal Gland NeoplasmsCarcinoma, NeuroendocrineChildDelayed DiagnosisFemaleHumansMaleMultiple Endocrine Neoplasia Type 2bMutationNeoplasm MetastasisPheochromocytomaProto-Oncogene Proteins c-retRetrospective StudiesThyroid NeoplasmsProto-Oncogene Proteins c-retRET protein, human

Identifiers

PMID30314660
PMCPMC6707507
OpenAlexW2896626543

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.