ArticleHeart & lung : the journal of critical care2018
Comparative symptom biochemistry between moderate and advanced heart failure.
Article in Heart & lung : the journal of critical care, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Characterising Multimorbidity in Adults With Heart Failure: A Latent Class Analysis.Heart, lung & circulation · 2026Article
- Sympathetic dysfunction is associated with worse fatigue and early and subtle symptoms in heart failure: an exploratory sex-stratified analysis.European journal of cardiovascular nursing · 2024Article
- Exploring gender differences in trajectories of clinical markers and symptoms after left ventricular assist device implantation.European journal of cardiovascular nursing · 2021Article
- Heart Failure Symptom Biology in Response to Ventricular Assist Device Implantation.The Journal of cardiovascular nursingArticle
- Identifying unique profiles of perceived dyspnea burden in heart failure.Heart & lung : the journal of critical careArticle
- Are Physical and Depressive Symptoms Different Between Women and Men With Heart Failure?: An Exploration Using Two Analytic Techniques.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundWe have a limited understanding of the biological underpinnings of symptoms in heart failure (HF).
objectivesThe purpose of this paper was to compare relationships between peripheral biomarkers of HF pathogenesis and physical symptoms between patients with advanced versus moderate HF.
methodsThis was a two-stage phenotype sampling cohort study wherein we examined patients with advanced HF undergoing ventricular assist device implantation in the first stage, and then patients with moderate HF (matched adults with HF not requiring device implantation) in the second stage. Linear modeling was used to compare relationships among biomarkers and physical symptoms between cohorts.
resultsWorse myocardial stress, systemic inflammation and endothelial dysfunction were associated with worse physical symptoms in moderate HF (n=48), but less physical symptom burden in advanced HF (n=48).
conclusionsWhere patients are in the HF trajectory needs to be taken into consideration when exploring biological underpinnings of physical HF symptoms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.