Evidence map›Paper›PMID 30314451›Full record

ArticleBMC nephrology2018

Home hemodialysis treatment and outcomes: retrospective analysis of the Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) cohort.

Shashidhar Cherukuri, Maria Bajo, Giacomo Colussi, Roberto Corciulo, Hafedh Fessi, Maxence Ficheux, Maria Slon, Eric Weinhandl, Natalie Borman

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in BMC nephrology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Observational
  4. Review
  5. Prescribing the dialysis dose and treatment frequency in home haemodialysis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 6 countries.

Shashidhar CherukuriRoyal Wolverhampton Hospital, Renal Services, Wolverhampton, England.
Maria BajoHospital Universitario La Paz, Servicio de Nefrologia, Madrid, Spain.
Giacomo ColussiNiguarda Hospital, Nefrologia - Centro Trapianti Rene, Milan, Italy.
Roberto CorciuloPoliclinic University, Azienda Ospedaliero-Universitaria Consorziale Policlinico, Bari, Italy.
Hafedh FessiHôpital Tenon, Service de Néphrologie et Dialyses, Paris, France.
Maxence FicheuxCHR Clémenceau, Service Néphrologie-Hémodialyse-Transplantation, Caen, France.
Maria SlonHospital de Navarra, Servicio de Nefrologia, Pamplona, Spain.
Eric WeinhandlNxStage Medical, Inc., 350 Merrimack Street, Lawrence, MA, 01843, USA. eweinhandl@nxstage.com.ORCID 0000-0001-8016-2015
Natalie BormanQueen Alexandra Hospital, Wessex Kidney Centre, Portsmouth, England.
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITAzienda Universitaria Ospedaliera Consorziale - Policlinico Bari · ITHôpital Georges-Clemenceau · FRHospital Universitario La Paz · ESQueen Alexandra Hospital · GBSorbonne Université · FRUniversity of Minnesota · USWolverhampton Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUtilization of home hemodialysis (HHD) is low in Europe. The Knowledge to Improve Home Dialysis Network in Europe (KIHDNEy) is a multi-center study of HHD patients who have used a transportable hemodialysis machine that employs a low volume of lactate-buffered, ultrapure dialysate per session. In this retrospective cohort analysis, we describe patient factors, HHD prescription factors, and biochemistry and medication use during the first 6 months of HHD and rates of clinical outcomes thereafter.

methodsUsing a standardized digital form, we recorded data from 7 centers in 4 Western European countries. We retained patients who completed ≥6 months of HHD. We summarized patient and HHD prescription factors with descriptive statistics and used mixed modeling to assess trends in biochemistry and medication use. We also estimated long-term rates of kidney transplant and death.

resultsWe identified 129 HHD patients; 104 (81%) were followed for ≥6 months. Mean age was 49 years and 66% were male. Over 70% of patients were prescribed 6 sessions per week, and the mean treatment duration was 15.0 h per week. Median HHD training duration was 2.5 weeks. Mean standard Kt/V

conclusionsIntensive HHD with low-flow dialysate delivers adequate urea clearance and good biochemical outcomes in Western European patients. Intensive HHD coincided with a large decrease in antihypertensive medication use. With relatively rapid training, HHD should be considered in more patients.

Indexed as

Hemodialysis, HomeAdultAntihypertensive AgentsBicarbonatesCalciumC-Reactive ProteinFemaleHumansKidney Failure, ChronicMaleMiddle AgedPhosphorusPotassiumRetrospective StudiesSerum AlbuminTreatment OutcomeAntihypertensive AgentsBicarbonatesCalciumC-Reactive ProteinPhosphorusPotassiumSerum AlbuminAdequacyAntihypertensive medicationHome hemodialysisIntensive hemodialysisKidney transplantLactateLow-flow dialysateUltrapure dialysate

Identifiers

PMID30314451
PMCPMC6186139
OpenAlexW2897844278

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.