Evidence map›Paper›PMID 30314397›Full record

ArticleMolecules (Basel, Switzerland)2018

Enzyme-Site Blocking Combined with Optimization of Molecular Docking for Efficient Discovery of Potential Tyrosinase Specific Inhibitors from

Haichun Liu, Yitian Zhu, Ting Wang, Jin Qi, Xuming Liu

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 25 citations in OpenAlex.

  1. Metabolomics reveal drought-stress responses in guayule, a semi-arid rubber crop.Metabolomics : Official journal of the Metabolomic Society · 2026
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  6. Evaluation of Anti-Melanogenesis Activity of EnrichedInternational journal of molecular sciences · 2021
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Haichun LiuJiangsu key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. tuna888@126.com.
Yitian ZhuJiangsu key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. amberzyt@outlook.com.ORCID 0000-0003-2174-2380
Ting WangJiangsu key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. wangting5_1991@163.com.
Jin QiJiangsu key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, China. qijin2006@163.com.
Xuming LiuSchool of Life Science and Technology, China Pharmaceutical University, Nanjing 211198, China. liuxm@cpu.edu.cn.
China Pharmaceutical University · CN

Funding

National Natural Science Foundation of China 81473317the Science and Technology Development Fund of Macao SAR 013/2015/A1
6 · The paper itself

Abstract

Enzyme inhibitors from natural products are becoming an attractive target for drug discovery and development; however, separating enzyme inhibitors from natural-product extracts is highly complex. In this study, we developed a strategy based on tyrosinase-site blocking ultrafiltration integrated with HPLC-QTOF-MS/MS and optimized molecular docking to screen tyrosinase inhibitors from

Indexed as

Molecular Docking SimulationMolecular Dynamics SimulationBinding SitesChromatography, High Pressure LiquidChromatography, LiquidDrugs, Chinese HerbalEnzyme ActivationEnzyme InhibitorsMass SpectrometryMonophenol MonooxygenaseProtein BindingPuerariaSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationStructure-Activity RelationshipDrugs, Chinese HerbalEnzyme InhibitorsMonophenol Monooxygenaseplant extract, Puerariae Radixaffinity-ultrafiltration-MSmolecular dockingtyrosinase inhibitors

Identifiers

PMID30314397
PMCPMC6222779
OpenAlexW2897313425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.