Evidence map›Paper›PMID 30314337›Full record

ArticleInternational journal of molecular sciences2018

Dysregulated Marginal Zone B Cell Compartment in a Mouse Model of Sjögren's Syndrome with Ocular Inflammation.

Niharika Singh, Ian Chin, Paul Gabriel, Emily Blaum, Sharmila Masli

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Article
  5. Ectopic lymphoid structures in the aged lacrimal glands.Clinical immunology (Orlando, Fla.) · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.International journal of molecular sciences · 2020
    Review
  10. Mechanisms of Disease in Sjögren Syndrome-New Developments and Directions.International journal of molecular sciences · 2020
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Niharika SinghDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA. nihsingh@bu.edu.ORCID 0000-0001-9177-4316
Ian ChinDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA. icgitar@bu.edu.ORCID 0000-0001-6506-9736
Paul GabrielDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA. paulg@bu.edu.
Emily BlaumDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA. eblaum@bu.edu.
Sharmila MasliDepartment of Ophthalmology, Boston University School of Medicine, Boston, MA 02118, USA. smasli@bu.edu.
Boston University · US

Funding

Massachusetts Lions Eye Research Fund BUSM-Ophthalmology
6 · The paper itself

Abstract

The risk of developing lymphoma in patients with Sjögren's syndrome (SS) is 44 times higher than in the normal population with the most common lymphomas derived from marginal zone B (MZB) cells. Current understanding of the role of MZB cells in SS is primarily based on salivary gland pathology, while their contextual association with lacrimal glands and ocular manifestations largely remains unknown. We examined this possibility using a SS mouse model (thrombospondin-1 deficient (TSP1

Indexed as

AnimalsAutoantibodiesB-Lymphocyte SubsetsCytokinesDisease Models, AnimalEndophthalmitisImmunity, InnateInflammation MediatorsLacrimal ApparatusLymphocyte CountLymphoid TissueMaleMiceMice, KnockoutSalivary GlandsSjogren's SyndromeAutoantibodiesCytokinesInflammation MediatorsThrombospondin 1autoantibodieslymphomamarginal zone B cellsSjögren’s syndromethrombospondin

Identifiers

PMID30314337
PMCPMC6213455
OpenAlexW2896208792

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.