Evidence map›Paper›PMID 30314325›Full record

ArticleMolecules (Basel, Switzerland)2018

Insulin Mimetic Properties of Extracts Prepared from

Renate Haselgrübler, Verena Stadlbauer, Flora Stübl, Bettina Schwarzinger, Ieva Rudzionyte, Markus Himmelsbach, Marcus Iken, Julian Weghuber

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Identification of Plant Phenolics fromJournal of agricultural and food chemistry · 2025
    Article
  3. Review
  4. Article
  5. Review
  6. A comprehensiveFrontiers in pharmacology · 2024
    Review
  7. (Bio)active Compounds in Daisy Flower (Molecules (Basel, Switzerland) · 2023
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Avens Root (Frontiers in pharmacology · 2021
    Article
  16. Article
  17. Super-Resolution Live Cell Microscopy of Membrane-Proximal Fluorophores.International journal of molecular sciences · 2020
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Renate HaselgrüblerSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. renate.haselgruebler@fh-wels.at.
Verena StadlbauerSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. verena.stadlbauer@fh-wels.at.
Flora StüblSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. flora.stuebl@fh-wels.at.
Bettina SchwarzingerSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. bettina.schwarzinger@fh-wels.at.
Ieva RudzionyteSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. ieva.rudzionyte@fh-wels.at.
Markus HimmelsbachInstitute for Analytical Chemistry, Johannes Kepler University, A-4040 Linz, Austria. markus.himmelsbach@jku.at.ORCID 0000-0002-0489-3534
Marcus IkenPM International AG, L-5445 Schengen, Luxembourg. marcus.iken@pm-international.de.
Julian WeghuberSchool of Engineering, University of Applied Sciences Upper Austria, Stelzhamerstrasse 23, A-4600 Wels, Austria. julian.weghuber@fh-wels.at.ORCID 0000-0001-6312-4666
University of Applied Sciences Upper Austria · ATINTRASOFT International (Luxembourg) · LUJohannes Kepler University of Linz · AT

Funding

Österreichische Forschungsförderungsgesellschaft 850681
6 · The paper itself

Abstract

Diabetes mellitus (DM) and consequential cardiovascular diseases lead to millions of deaths worldwide each year; 90% of all people suffering from DM are classified as Type 2 DM (T2DM) patients. T2DM is linked to insulin resistance and a loss of insulin sensitivity. It leads to a reduced uptake of glucose mediated by glucose transporter 4 (GLUT4) in muscle and adipose tissue, and finally hyperglycemia. Using a fluorescence microscopy-based screening assay we searched for herbal extracts that induce GLUT4 translocation in the absence of insulin, and confirmed their activity in chick embryos. We found that extracts prepared from

Indexed as

Biological MimicryAnimalsAsteraceaeBiological TransportBlood GlucoseChick EmbryoCHO CellsChromatography, High Pressure LiquidCricetulusGlucoseGlucose Transporter Type 4HumansInsulinPlant ExtractsProtein TransportBlood GlucoseGlucoseGlucose Transporter Type 4InsulinPlant ExtractsBellis perennis extractglucose uptakeGLUT4 translocationhens egg test-chorioallantoic membrane (HET-CAM) assayinsulin mimetic propertytype 2 diabetes

Identifiers

PMID30314325
PMCPMC6222741
OpenAlexW2897413395

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.