ArticleDrug and alcohol dependence2018
Multicomorbidity of chronic diseases and substance use disorders and their association with hospitalization: Results from electronic health records data.
Article in Drug and alcohol dependence, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
92 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Exploring linkages between drought and HIV treatment adherence in Africa: a systematic review.The Lancet. Planetary health · 2022Pooled it
- eHealth Interventions to Treat Substance Use in Pregnancy: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Addiction Consult Services, Mortality, and Acute Care Utilization in Inpatients With Opioid Use Disorder: A Secondary Analysis of a Cluster Randomized Clinical Trial.JAMA network open · 2025Trial
- Baseline gut microbiome and metabolites are correlated with changes in alcohol consumption in participants in a randomized Zonisamide clinical trial.Scientific reports · 2025Trial
- Examining Access to Primary Care for People With Opioid Use Disorder in Ontario, Canada: A Randomized Clinical Trial.JAMA network open · 2022Trial
- Preventing Hospital Readmission for Patients With Comorbid Substance Use Disorder : A Randomized Trial.Annals of internal medicine · 2021Trial
- Substance Use Disorder Detection Rates Among Providers of General Medical Inpatients.Journal of general internal medicine · 2021Trial
- Equity-Related Determinants of Frequent Emergency Department Visits for Substance Use Disorders: A Population-Based Study in Ontario, Canada.The International journal of social psychiatry · 2026Article
- Risk of Mortality Associated With Substance Use Disorder in Korea: A National Population-Based Study.Journal of Korean medical science · 2026Article
- Health insurance type moderates the association between substance use disorders and cardiovascular multimorbidity among U.S. adults - Results from the 2023 National Survey on Drug use and Health.Substance abuse treatment, prevention, and policy · 2026Article
- Understanding patterns of behavioral health referrals for chronic disease in integrated care settings.BMC primary care · 2026Article
- Chronic Disease Management Among People Treated for Comorbid Serious Mental Illness and/or Substance Use Disorders: A Population-Based Observational Study.Community mental health journal · 2026Article
- Burden of all-cause and cause-specific mortality among individuals with medications for treatment of opioid use disorder: A matched cohort study from 4 US health systems, 2012-2021.Journal of substance use and addiction treatment · 2026Article
- Complementary services improve recovery outcomes among college students with alcohol or other drug related use disorders.Scientific reports · 2026Article
- High Levels of Substance Use Disorder Among Critically Ill Virginia Medicaid Beneficiaries.Journal of addiction medicine · 2026Article
- A qualitative investigation of experiences of care and illness perceptions related to self-management behaviors in chronic kidney disease.Health psychology and behavioral medicine · 2026Article
- Compounding risks of chronic health conditions and substance use disorder on healthcare burden in the USA: Analysis of NSDUH data (2021-2023).Addictive behaviors reports · 2025Article
- Health-related quality of life measures as predictors for recurrent hospitalization and mortality among patients in heroin-assisted treatment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025Article
- Alcohol Use Predicts Longer But More Fragmented Sleep: A Daily Diary Study of Alcohol, Sleep, and PTSD in Nurses.International journal of behavioral medicine · 2025Article
- Behavioural risk factors clusters and their associations with self-reported burdens among university students in Finland.Central European journal of public health · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
backgroundChronic diseases are prevalent and the leading causes of mortality. Comorbidity of substance use disorders (SUDs) and chronic diseases is understudied to inform behavioral healthcare integration.
objectivesThis study leveraged electronic health record (EHR) data of 211,880 adults from a large health system to examine prevalence and correlates of comorbidity of SUDs and nine chronic disease groups and to determine their association with hospitalization.
methodsLogistic regression analyses were conducted to estimate associations between chronic diseases and SUDs. To control for severity of diagnosis, analyses of associations between SUD and hospitalization were stratified by the number of chronic conditions.
resultsIn the sample, 48.3% had ≥1 chronic condition (hypertension 33.7%, arthritis 16.2%, diabetes 13.7%, chronic kidney disease 9.9%, asthma 9.1%, chronic obstructive pulmonary disease 8.9%, ischemic heart disease 8.3%, cancer 4.6%, and hepatitis 1.3%). Prevalence of SUD (overall 13.3%) among patients increased with multiple chronic conditions (14.3% having SUD among patients with one condition; 21.2% having SUD among patients with two to three conditions; and 32.5% having SUD among patients with 4-9 conditions). Chronic conditions were associated with increased odds of SUDs. For all SUD groups, hospitalization was more prevalent among patients with SUD than those without it; prevalence of hospitalization increased with the number of comorbid chronic conditions.
conclusionsFindings reveal a striking pattern of multicomorbidity of SUD and chronic diseases and its positive association with hospitalization. Behavioral healthcare integration should consider efforts to assess and treat comorbid SUD and chronic diseases, especially among adults with multiple chronic conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.