Evidence map›Paper›PMID 30312809›Full record

ArticleNeuroImage2019

Depth-dependent intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging.

Emma Sprooten, Rafael O'Halloran, Juliane Dinse, Won Hee Lee, Dominik Andreas Moser, Gaelle Eve Doucet, Morgan Goodman, Hannah Krinsky, Alejandro Paulino, Alexander Rasgon and 4 more

Abstract read
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Emma SprootenCentre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands; Department of Cognitive Neuroscience, Radboudumc, Nijmegen, the Netherlands.
Rafael O'HalloranTranslational and Molecular Imaging Institute Translational and Molecular Imaging Institute and Brain Imaging Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Juliane DinseDepartment of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.
Won Hee LeeDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Dominik Andreas MoserDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Gaelle Eve DoucetDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Morgan GoodmanDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hannah KrinskyDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alejandro PaulinoDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Alexander RasgonDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Evan LeibuDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Priti BalchandaniTranslational and Molecular Imaging Institute Translational and Molecular Imaging Institute and Brain Imaging Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matilde IngleseDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Sophia FrangouDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address: sophia.frangou@mssm.edu.

Funding

Brain connectivity and the role of myelin in PsychosisR01MH113619 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FRANGOU, SOPHIA · 2018 to 2021
$2.5M
NIMH NIH HHS R01 MH113619
6 · The paper itself

Abstract

backgroundIntracortical myelin is a key determinant of neuronal synchrony and plasticity that underpin optimal brain function. Magnetic resonance imaging (MRI) facilitates the examination of intracortical myelin but presents with methodological challenges. Here we describe a whole-brain approach for the in vivo investigation of intracortical myelin in the human brain using ultra-high field MRI.

methodsTwenty-five healthy adults were imaged in a 7 Tesla MRI scanner using diffusion-weighted imaging and a T

resultsIntracortical T

conclusionsWe demonstrate the usefulness of an automatic, whole-brain method to perform depth-dependent examination of intracortical myelin organization. The extracted metrics, T

Indexed as

Myelin SheathAdultBrainDiffusion Magnetic Resonance ImagingFemaleHumansImage Processing, Computer-AssistedMaleNeuroimagingCortical depth-levelsMyeloarchitectureNeuroimagingUltra-high field

Identifiers

PMID30312809
PMCPMC6289812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.