ArticleNeuroImage2019
Glutamatergic facilitation of neural responses in MT enhances motion perception in humans.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- GABA, Glutamate and Neural Activity: A Systematic Review With Meta-Analysis of MultimodalFrontiers in psychiatry · 2021Pooled it
- Directional Motion Sensitivity in Visual Snow Syndrome and Its Relation to Trailing-Type Palinopsia.Investigative ophthalmology & visual science · 2025Article
- Linking cortical surface area to computational properties in human visual perception.iScience · 2024Article
- Abnormal activation patterns in MT+ during visual motion perception in major depressive disorder.Frontiers in psychiatry · 2024Article
- GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients.Communications biology · 2023Article
- Neurotypicals with higher autistic traits have delayed visual processing of an approaching life-sized avatar's gait: an event-related potentials study.Frontiers in human neuroscience · 2023Article
- Investigating the neurochemistry of the human visual system using magnetic resonance spectroscopy.Brain structure & function · 2022Review
- Neurochemical and functional interactions for improved perceptual decisions through training.Journal of neurophysiology · 2022Article
- The association between language-based task-functional magnetic resonance imaging hemodynamics and baseline GABA+ and glutamate-glutamine measured in pre-supplementary motor area: A pilot study in an aging model.Frontiers in psychiatry · 2022Article
- Migraine Visual Aura and Cortical Spreading Depression-Linking Mathematical Models to Empirical Evidence.Vision (Basel, Switzerland) · 2021Article
- Concentrations of Cortical GABA and Glutamate in Young Adults With Autism Spectrum Disorder.Autism research : official journal of the International Society for Autism Research · 2020Article
- Weaker neural suppression in autism.Nature communications · 2020Article
- Response Dissociation in Hierarchical Cortical Circuits: a Unique Feature of Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Late fMRI Response Components Are Altered in Autism Spectrum Disorder.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
There is large individual variability in human neural responses and perceptual abilities. The factors that give rise to these individual differences, however, remain largely unknown. To examine these factors, we measured fMRI responses to moving gratings in the motion-selective region MT, and perceptual duration thresholds for motion direction discrimination. Further, we acquired MR spectroscopy data, which allowed us to quantify an index of neurotransmitter levels in the region of area MT. These three measurements were conducted in separate experimental sessions within the same group of male and female subjects. We show that stronger Glx (glutamate + glutamine) signals in the MT region are associated with both higher fMRI responses and superior psychophysical task performance. Our results suggest that greater baseline levels of glutamate within MT facilitate motion perception by increasing neural responses in this region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.