Evidence map›Paper›PMID 30312530›Full record

ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2019

Liver transplantation and waitlist mortality for HCC and non-HCC candidates following the 2015 HCC exception policy change.

Tanveen Ishaque, Allan B Massie, Mary G Bowring, Christine E Haugen, Jessica M Ruck, Samantha E Halpern, Madeleine M Waldram, Macey L Henderson, Jacqueline M Garonzik Wang, Andrew M Cameron and 4 more

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04530240 (Impact of National MELD ≥ 30 Priority Allocation System on Dropout and Post-Transplant Survival Rates in Italy), which is not on this map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04530240 completednot on this map

Impact of National MELD ≥ 30 Priority Allocation System on Dropout and Post-Transplant Survival Rates in Italy: A Retrospective Competing-Risk Analysis

TypeobservationalSponsorUniversity of BolognaRan2010 to 2019Enrolled4,238ConditionsLiver Transplant Disorder, HCCArmsLiver Transplantation
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. The UK National Appeals Panel Safely Extends Access to Liver Transplantation for Candidates Beyond Standard Listing Criteria.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Article
  4. Article
  5. Article
  6. Article
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  8. Article
  9. Liver transplantation for colorectal liver metastasis: aiming for a cure or a palliation?Transplant international : official journal of the European Society for Organ Transplantation · 2021
    Article
  10. MELD is MELD is MELD? Transplant center-level variation in waitlist mortality for candidates with the same biological MELD.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2021
    Article
  11. Article
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  15. How do highly sensitized patients get kidney transplants in the United States? Trends over the last decade.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  16. Review
  17. Unfair Advantages for Hepatocellular Carcinoma Patients Listed for Liver Transplant in Short-Wait Regions Following 2015 Hepatocellular Carcinoma Policy Change.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2020
    Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Tanveen IshaqueDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-3523-243X
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Mary G BowringDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-7299-7730
Christine E HaugenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-5884-2604
Jessica M RuckDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-5749-5505
Samantha E HalpernDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Madeleine M WaldramDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0001-5706-4353
Macey L HendersonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.ORCID 0000-0002-4239-1252
Jacqueline M Garonzik WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Andrew M CameronDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Benjamin PhilosopheDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Shane OttmannDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Anne F RositchDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Johns Hopkins University · US

Funding

Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Technological Innovations for Live Kidney Donor Follow-up Care ManagementK01DK114388 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVAN, MACEY LEIGH · 2017 to 2021
$720k
Novel Frailty Phenotype in Older Adults with End-Stage Renal DiseaseF32AG053025 · NIA · JOHNS HOPKINS UNIVERSITY · PI HAUGEN, CHRISTINE · 2016 to 2019
$204k
NIAID NIH HHS K24 AI144954NIA NIH HHS F32 AG053025NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K01 DK114388NIDDK NIH HHS K24 DK101828
6 · The paper itself

Abstract

Historically, exception points for hepatocellular carcinoma (HCC) led to higher transplant rates and lower waitlist mortality for HCC candidates compared to non-HCC candidates. As of October 2015, HCC candidates must wait 6 months after initial application to obtain exception points; the impact of this policy remains unstudied. Using 2013-2017 SRTR data, we identified 39  350 adult, first-time, active waitlist candidates and compared deceased donor liver transplant (DDLT) rates and waitlist mortality/dropout for HCC versus non-HCC candidates before (October 8, 2013-October 7, 2015, prepolicy) and after (October 8, 2015-October 7, 2017, postpolicy) the policy change using Cox and competing risks regression, respectively. Compared to non-HCC candidates with the same calculated MELD, HCC candidates had a 3.6-fold higher rate of DDLT prepolicy (aHR =

Indexed as

Patient SelectionAgedCarcinoma, HepatocellularFemaleFollow-Up StudiesHumansLiver NeoplasmsLiver TransplantationMaleMiddle AgedPrognosisProspective StudiesResource AllocationRisk AssessmentSeverity of Illness IndexTissue and Organ Procurementcancer/malignancy/neoplasiaclinical research/practicedisparitiesgraft survivalliver disease: malignantliver transplantation/hepatologyorgan allocation

Identifiers

PMID30312530
PMCPMC6349527
OpenAlexW2896531953

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.