ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
Antibiotics release from cement spacers used for two-stage treatment of implant-associated infections after total joint arthroplasty.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Current and emerging antibacterial strategies for periprosthetic joint infection: An overview.Bioactive materials · 2026Review
- Extensor mechanism injury/failure following spacer dislocation in periprosthetic joint infection: a case series in a single reference center.Musculoskeletal surgery · 2026Article
- CarboCell G/C provides sustained high local bone antibiotic levels with minimal systemic exposure, supporting its therapeutic potential in orthopedic infection management.Journal of bone and joint infection · 2026Article
- In Vivo Antibiotic Elution and Inflammatory Response During Two-Stage Total Knee Arthroplasty Revision: A Microdialysis Pilot Study.Antibiotics (Basel, Switzerland) · 2025Article
- Treatment of Periprosthetic Joint Infection with Intravenous Vancomycin: Do We Hit the Target?Antibiotics (Basel, Switzerland) · 2024Article
- Are Static Spacers Superior to Articulated Spacers in the Staged Treatment of Infected Primary Knee Arthroplasty? A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2022Review
- Preparation and in vivo bacteriostatic application of PPDO-coated Ag loading TiOScientific reports · 2022Article
- Intra-articular versus systemic vancomycin for the treatment of periprosthetic joint infection after debridement and spacer implantation in a rat model.Bone & joint research · 2022Article
- Reconstruction of Tumor-Induced Pelvic Defects With Customized, Three-Dimensional Printed Prostheses.Frontiers in oncology · 2022Article
- Comparing the Efficacy of Articulating Spacers in Two-Stage Revision for Periprosthetic Joint Infection Following Total Knee Arthroplasty: All-Cement Spacers vs Sterilized Replanted Metal-Polyethylene Spacers.International journal of general medicine · 2022Article
- Total hip revision with custom-made spacer and prosthesis: A case report.World journal of clinical cases · 2021Article
- The Combined Use of Gentamicin and Silver Nitrate in Bone Cement for a Synergistic and Extended Antibiotic Action against Gram-Positive and Gram-Negative Bacteria.Materials (Basel, Switzerland) · 2021Article
- Periprosthetic Joint Infection Caused byInternational journal of general medicine · 2021Article
- Antibiotics release from cement spacers used for two-stage treatment of implant-associated infections after total joint arthroplasty.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Two-stage revision arthroplasty is the treatment of choice for periprosthetic infection, a serious complication after knee or hip arthroplasty. Our prospective clinical trial aimed to investigate the concentrations of gentamicin and vancomycin in wound exudate and tissue in two-stage revision arthroplasty. Wound exudate and periprosthetic membrane samples were collected from 18 patients (10 hip and eight knee patients), who were due for two-stage treatment after a periprosthetic joint infection. Samples were taken during insertion of antibiotic-impregnated spacers and after their removal. The concentrations of gentamicin and vancomycin in wound exudates and adjacent tissue were analyzed using high-performance liquid chromatography mass spectrometry. Average time period of spacer implantation was 13.6 weeks (9.3-22.6 weeks). The concentration of vancomycin in wound exudate decreased from a median of 43.28 μg/mL (0.28-261.22) after implantation to 0.46 μg/mL (0.13-37.47) after the removal of the spacer. In the adjacent tissue, vancomycin concentration was mainly undetectable prior to spacer implantation (0.003 μg/g [0.003-0.261]) and increased to 0.318 μg/g [0.024-484.16] at the time of spacer removal. This was also observed for gentamicin in the tissue of patients who previously had cement-free implants (0.008 μg/g [0.008-0.087] vs. 0.164 μg/g [0.048-71.75]) while in the tissue of patients with previously cemented prosthesis, baseline concentration was already high (8.451 μg/g [0.152-42.926]). Despite the rapid decrease in antibiotics release from spacer cement observed in vitro, in vivo antibiotics are much longer detectable, especially in the adjacent soft tissue. © 2018 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials Published By Wiley Periodicals, Inc. J Biomed Mater Res B Part B, 2019. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1587-1597, 2019.
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