ArticleMolecular plant pathology2019
Contribution of a lectin, LecM, to the quorum sensing signalling pathway of Ralstonia solanacearum strain OE1-1.
Article in Molecular plant pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 31 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Two ferric uptake regulator proteins inApplied and environmental microbiology · 2026Article
- Contribution of a Novel TetR/AcrR Family Transcriptional Regulator RalT of Ralstonia pseudosolanacearum Strain OE1-1 to the Fine-Tuning of Its Virulence.MicrobiologyOpen · 2026Article
- The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes inMicrobiology spectrum · 2025Article
- Lectins and polysaccharide EPS I have flow-responsive roles in the attachment and biofilm mechanics of plant pathogenic Ralstonia.PLoS pathogens · 2024Article
- N-acyl homoserine lactone cell-cell diffusible signalling in the Ralstonia solanacearum species complex.Molecular plant pathology · 2024Review
- Microbiome-Mediated Strategies to Manage Major Soil-Borne Diseases of Tomato.Plants (Basel, Switzerland) · 2024Review
- Transcriptomic profiling reveals host-specific evolutionary pathways promoting enhanced fitness in the plant pathogenMicrobial genomics · 2023Article
- The transcription regulator ChpA affects the global transcriptome including quorum sensing-dependent genes in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- Quorum Sensing-Dependent Invasion of Ralstonia solanacearum into Fusarium oxysporum Chlamydospores.Microbiology spectrum · 2023Article
- β-1,4-Cellobiohydrolase is involved in full expression of phcA, contributing to the feedback loop in quorum sensing of Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2023Article
- Biocomputational Assessment of Natural Compounds as a Potent Inhibitor to Quorum Sensors inMolecules (Basel, Switzerland) · 2022Article
- PhcQ mainly contributes to the regulation of quorum sensing-dependent genes, in which PhcR is partially involved, in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2021Article
- Light modulates important physiological features of Ralstonia pseudosolanacearum during the colonization of tomato plants.Scientific reports · 2021Article
- Convergent Rewiring of the Virulence Regulatory Network Promotes Adaptation of Ralstonia solanacearum on Resistant Tomato.Molecular biology and evolution · 2021Article
- The putative sensor histidine kinase PhcK is required for the full expression of phcA encoding the global transcriptional regulator to drive the quorum-sensing circuit of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2020Article
- Article
- Major exopolysaccharide, EPS I, is associated with the feedback loop in the quorum sensing of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2019Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The soil-borne bacterium Ralstonia solanacearum invades the roots and colonizes the intercellular spaces and then the xylem. The expression of lecM, encoding a lectin LecM, is induced by an OmpR family response regulator HrpG in R. solanacearum strain OE1-1. LecM contributes to the attachment of strain OE1-1 to the host cells of intercellular spaces. OE1-1 produces methyl 3-hydroxymyristate (3-OH MAME) through a methyltransferase (PhcB) and extracellularly secretes the chemical as a quorum sensing (QS) signal, which activates QS. The expression of lecM is also induced by the PhcA virulence regulator functioning through QS, and the resulting LecM is implicated in the QS-dependent production of major exopolysaccharide EPS I and the aggregation of OE1-1 cells. To investigate the function of LecM in QS, we analysed the transcriptome of R. solanacearum strains generated by RNA sequencing technology. In the lecM mutant, the expression of positively QS-regulated genes and negatively QS-regulated genes was down-regulated (by >90%) and up-regulated (by ~60%), respectively. However, phcB and phcA in the lecM mutant were expressed at levels similar to those in strain OE1-1. The lecM mutant produced significantly less ralfuranone and exhibited a significantly greater swimming motility, which were positively and negatively regulated by QS, respectively. In addition, the extracellular 3-OH MAME content of the lecM mutant was significantly lower than that of OE1-1. The application of 3-OH MAME more strongly increased EPS I production in the phcB-deleted mutant and strain OE1-1 than in the lecM mutant. Thus, the QS-dependent production of LecM contributes to the QS signalling pathway.
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