Evidence map›Paper›PMID 30312457›Full record

ArticleJournal of the National Cancer Institute2019

Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study.

Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C Oosterwijk, Wendy K Chung, D Gareth Evans, Christoph Engel and 140 more

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Article in Journal of the National Cancer Institute, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.

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25citing papers in PubMed, 2 pooled it
–field-weighted citation impact
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3 · Its place in the literature

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25 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  4. Complex Interplay Between Obesity and BRCA1/2-Associated Breast Cancer: An Overview.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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5 · Who and what money

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150 authors.

Frank QianDepartment of Medicine, The University of Chicago, Chicago, IL.
Shengfeng WangCenter for Clinical Cancer Genetics, The University of Chicago, Chicago, IL.
Jonathan MitchellDivision of Gastroenterology, Department of Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA.
Lesley McGuffogDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Daniel BarrowdaleDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Goska LeslieDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Jan C OosterwijkDepartment of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Wendy K ChungDepartments of Pediatrics and Medicine, Columbia University, New York, NY.
D Gareth EvansDivision of Evolution and Genomic Sciences, Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, UK.
Christoph EngelInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Karin KastDepartment of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany.
Cora M AalfsDepartment of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
Muriel A AdankFamily Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
Julian AdlardYorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK.
Bjarni A AgnarssonDepartment of Pathology, National Institute of Oncology, Budapest, Hungary.
Kristiina AittomäkiDepartment of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Elisa AlducciImmunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
Banu K ArunDepartment of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX.
Margreet G E M AusemsDepartment of Medical Genetics, University Medical Center, Utrecht, the Netherlands.
Jacopo AzzolliniUnit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
Emmanuelle Barouk-SimonetOncogénétique, Institut Bergonié, Bordeaux, France.
Julian BarwellLeicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.
Muriel BelottiService de Génétique, Institut Curie, Paris, France.
Javier BenitezSchools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA.
Andreas BergerDepartment of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
Ake BorgCancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA.
Angela R BradburyDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Joan BrunetService de Génétique, Institut Curie, Paris, France.
Saundra S BuysDepartment of Medicine, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT.
Trinidad CaldesMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain.
Maria A CaligoSection of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
Ian CampbellPeter MacCallum Cancer Center, Melbourne, Victoria, Australia.
Sandrine M CaputoLeicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK.
Jocelyne ChiquetteUnité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada.
Kathleen B M ClaesCentre for Medical Genetics, Ghent University, Ghent, Belgium.
J Margriet ColléeDepartment of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
Fergus J CouchDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
Isabelle CoupierUnité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA.
Rosemarie DavidsonDepartment of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
Orland DiezN.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Susan M DomchekDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Alan DonaldsonOncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain (OD); Clinical Genetics Department, St Michael's Hospital, Bristol, UK.
Cecilia M DorflingDepartment of Genetics, University of Pretoria, Arcadia, South Africa.
Ros EelesOcogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
Lidia FeliubadalóCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Lenka ForetovaMolecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology, Bellvitge Biomedical Research Institute), CIBERONC, Barcelona, Spain.
Jeffrey FowlerThe Ohio State University, Columbus Cancer Council, Columbus, OH.
Eitan FriedmanThe Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Debra FrostDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Patricia A GanzSchools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA.
Judy GarberCancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA.
Vanesa Garcia-BarberanMolecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain.
Gord GlendonFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
Andrew K GodwinDepartment of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS.
Encarna B Gómez GarciaDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Jacek GronwaldDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Eric HahnenCenters for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Ute Hamann
Alex HendersonInstitute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.
Carolyn B HendricksCity of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA.
John L HopperCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Peter J HulickCenter for Medical Genetics, NorthShore University HealthSystem, Evanston, IL.
Evgeny N ImyanitovN.N. Petrov Institute of Oncology, St. Petersburg, Russia.
Claudine IsaacsLombardi Comprehensive Cancer Center, Georgetown University, Washington, DC (CI).
Louise IzattClinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Ángel IzquierdoGenetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.
Anna JakubowskaDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Katarzyna KaczmarekDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Eunyoung KangDepartment of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
Beth Y KarlanWomen's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
Carolien M KetsDepartment of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
Sung-Won KimDepartment of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea.
Zisun KimDepartment of Surgery, Soonchunhyang University Hospital Bucheon, Bucheon, Korea.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong.
Yael LaitmanThe Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
Christine LassetUnité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
Min Hyuk LeeDepartment of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea.
Jong Won LeeDepartment of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea.
Jihyoun LeeDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Jenny LesterDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Fabienne LesueurGenetic Epidemiology of Cancer team, Institut Curie, Paris, France.
Jennifer T LoudClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Jan LubinskiDepartment of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
Noura MebiroukGenetic Epidemiology of Cancer team, Institut Curie, Paris, France.
Hanne E J Meijers-HeijboerDepartment of Clinical Genetics, VU University Medical Center, Amsterdam, the Netherlands.
Alfons MeindlDivision of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Austin MillerDivision of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany.
Marco MontagnaDepartment of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Thea M MooijDepartment of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Patrick J MorrisonCentre for Cancer Research and Cell Biology, Queens University Belfast, Belfast, UK.
Emmanuelle Mouret-FourmeService de Génétique, Institut Curie, Paris, France.
Katherine L Nathanson
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of City of Hope, Duarte, CA.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Dieter NiederacherDepartment of Gynecology and Obstetrics, University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Finn C NielsenCenter for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Robert L NussbaumCancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA.
Kenneth OffitClinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY.
Edith OlahDepartment of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
Kai-Ren OngWest Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK.
Laura OttiniDepartment of Molecular Medicine, University La Sapienza, Rome, Italy.
Sue K ParkDepartments of Preventive Medicine and Biomedical Sciences, and Cancer Research Institute, Seoul National University, Seoul, Korea.
Paolo PeterlongoIFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
Georg PfeilerDepartment of Urology, Medical University of Vienna, Vienna, Austria.
Catherine M PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL.
Bruce PoppeCentre for Medical Genetics, Ghent University, Ghent, Belgium.
Nisha PradhanClinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
Susan J RamusSchool of Women's and Children's Health, University of New South Wales Sydney, New South Wales, Australia.
Johanna RantalaClinical Genetics, Karolinska Institutet, Stockholm, Sweden.
Mark RobsonClinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.
Gustavo C RodriguezDivision of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL.
Rita K SchmutzlerCenters for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Christina G Hutten SelkirkCenter for Medical Genetics, NorthShore University HealthSystem, Evanston, IL.
Payal D ShahDepartment of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Jacques SimardLaboratoire de génétique médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France.
Christian F SingerDepartment of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
Johanna SokolowskaGenomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, QC, Canada.
Dominique Stoppa-LyonnetDepartment of Tumour Biology, Institut Curie, INSERM U830, Paris, France.
Christian SutterInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Yen Yen TanCentro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
R Manuel TeixeiraDepartment of Genetics, Portuguese Oncology Institute, Porto, Portugal.
Soo H TeoCancer Research Malaysia, Subang Jaya, Selangor, Malaysia.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
Mads ThomassenDepartment of Clinical Genetics, Odense University Hospital, Odense C, Denmark.
Marc TischkowitzProgram in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada.
Amanda E TolandDepartment of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.
Katherine M TuckerSchool of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Nadine TungDepartment of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.
Christi J van AsperenDepartment of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Klaartje van EngelenDepartment of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
Elizabeth J van RensburgDepartment of Genetics, University of Pretoria, Arcadia, South Africa.
Shan Wang-GohrkeDepartment of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
Barbara WappenschmidtCenters for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jeffrey N WeitzelClinical Cancer Genetics, City of Hope, Duarte, CA.
Drakoulis YannoukakosMolecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
GEMO Study Collaborators
HEBON
EMBRACE
Mark H GreeneClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
Matti A RookusDepartment of Epidemiology, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Douglas F EastonDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Georgia Chenevix-TrenchDepartment of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Antonis C AntoniouDepartment of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
David E GoldgarDepartment of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT.
Olufunmilayo I OlopadeDepartment of Medicine, The University of Chicago, Chicago, IL.
Timothy R RebbeckHarvard T.H. Chan School of Public Health, Boston, MA.
Dezheng HuoDepartment of Medicine, The University of Chicago, Chicago, IL.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NRG Oncology Network Group Operations Center - GY9 BIQSFP Reports/BudgetsU10CA180868 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI NORMAN WOLMARK · 2014 to 2026
$206.8M
NRG Oncology NCORP Research Base-BIQSFPUG1CA189867 · NCI · NRG ONCOLOGY FOUNDATION, INC. · PI Deborah Watkins Bruner, Lisa A. Kachnic · 2014 to 2026
$140.5M
Clinical Genetic Studies of Familial and Hereditary Cancer SyndromesZIACP010144 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI SAVAGE, SHARON A. · 2009 to 2025
$111.8M
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Variation in Hormone and xenobiotic metabolizing enzyme genes and breast cancerP50CA125183 · NCI · UNIVERSITY OF CHICAGO · PI COX, NANCY · 2006 to 2010
$11.3M
Epidemiologic StudiesU19CA148065 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI AHSAN, HABIBUL, BRUGGE, JOAN SIEFERT · 2010 to 2014
$10.6M
Epidemiological and Clinical Translational Studies Post Genome-Wide AssociationU19CA148537 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EASTON, DOUGLAS FREDERICK, EELES, ROSALIND · 2010 to 2014
$10.4M
Network Lead Academic Participating Site: Memorial Sloan Kettering Cancer CenterUG1CA233290 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI CAROL AGHAJANIAN, Darren Feldman · 2019 to 2026
$10.2M
Cancer Research UK 10118Cancer Research UK 11174Cancer Research UK 20861Cancer Research UK 23382NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001863NCI NIH HHS F32 CA162847NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA116201NCI NIH HHS P50 CA125183NCI NIH HHS R01 CA128978NCI NIH HHS R01 CA142996NCI NIH HHS R01 CA214545NCI NIH HHS R25 CA112486NCI NIH HHS RC4 CA153828NCI NIH HHS U01 CA161032NCI NIH HHS U10 CA180868NCI NIH HHS U19 CA148065NCI NIH HHS U19 CA148112NCI NIH HHS U19 CA148537NCI NIH HHS UG1 CA189867NCI NIH HHS UG1 CA233191NCI NIH HHS UG1 CA233290NCI NIH HHS UM1 CA164920Wellcome Trust 203477/Z/16/Z
6 · The paper itself

Abstract

backgroundBRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear.

methodsWe used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided.

resultsObserved height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer.

conclusionHeight is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.

Indexed as

Body HeightBody Mass IndexMendelian Randomization AnalysisMutationAdultBRCA1 ProteinBRCA2 ProteinBreast NeoplasmsFemaleGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotidePrognosisRisk FactorsBRCA1 ProteinBRCA1 protein, humanBRCA2 ProteinBRCA2 protein, human

Identifiers

PMID30312457
PMCPMC6449171

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