Evidence map›Paper›PMID 30312404›Full record

ArticleInternational journal of epidemiology2018

Diet-quality scores and the risk of symptomatic gallstone disease: a prospective cohort study of male US health professionals.

Janine Wirth, Mingyang Song, Teresa T Fung, Amit D Joshi, Fred K Tabung, Andrew T Chan, Cornelia Weikert, Michael Leitzmann, Walter C Willett, Edward Giovannucci and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of epidemiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Association between dietary advanced glycation end products and gallstone disease: A case-control study.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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  16. RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models.Evidence-based complementary and alternative medicine : eCAM · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Janine WirthDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Mingyang SongDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Teresa T FungDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Amit D JoshiClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Fred K TabungDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Andrew T ChanClinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Cornelia WeikertFederal Institute of Risk Assessment, Department of Food Safety, Berlin, Germany.
Michael LeitzmannDepartment of Epidemiology and Preventive Medicine, Regensburg University, Regensburg, Germany.
Walter C WillettDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Edward GiovannucciDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Kana WuDepartment of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Harvard University · USFederal Institute for Risk Assessment · DEMassachusetts General Hospital · USSimmons University · USUniversity of Regensburg · DE

Funding

Dietary Etiology of Heart DiseaseR01HL035464 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ERIC B RIMM, Qi Sun · 1986 to 2026
$13.6M
Cancer Epidemiology Cohort in Male Health ProfessionalsUM1CA167552 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2012 to 2016
$11.5M
Mentored Patient-Oriented Research in Digestive DiseasesK24DK098311 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHAN, ANDREW T · 2013 to 2017
$930k
Risk Prediction of Symptomatic Gallbladder DiseaseK01DK110267 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI JOSHI, AMIT DOLAR · 2016 to 2021
$876k
Proinflammatory and hyperinsulinemic dietary patterns and colorectal cancer risk: role of the metabolomeK99CA207736 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI TABUNG, FRED KINYUY · 2016 to 2017
$276k
Marine Omega-3 Polyunsaturated Fatty Acid, Gut Microbiome, and Colorectal Cancer PreventionK99CA215314 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI SONG, MINGYANG · 2018 to 2018
$179k
NCI NIH HHS K99 CA207736NCI NIH HHS K99 CA215314NCI NIH HHS UM1 CA167552NHLBI NIH HHS R01 HL035464NIDDK NIH HHS K01 DK110267NIDDK NIH HHS K24 DK098311
6 · The paper itself

Abstract

Objective: To investigate the association between three diet-quality scores corresponding to adherence to healthy dietary patterns [alternate Mediterranean (aMed), Alternate Healthy Eating Index (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH)] and the risk of symptomatic gallstone disease. Methods: The study comprised 43 635 men of the Health Professionals Follow-up Study-an ongoing prospective cohort study of US health professionals. Participants were free of symptomatic gallstone disease and diabetes and provided dietary information every 4 years from 1986 (baseline) until 2012. The aMed, AHEI-2010 and DASH scores were generated and associated with the risk of symptomatic gallstone disease using Cox proportional hazards regression. Results: During 716 904 person-years of follow-up, 2382 incident cases of symptomatic gallstone disease were identified. All three scores were inversely associated with risk of symptomatic gallstone disease after adjustment for potential confounders including age, smoking, physical activity, energy and coffee intake [hazard ratios (HRs) and 95% confidence intervals (CIs)] comparing the highest with the lowest quintiles: aMed: 0.66 (0.57-0.77), AHEI-2010: 0.64 (0.56-0.74) and DASH: 0.66 (0.58-0.76)]. Findings were similar after additional adjustment for body mass index and after inclusion of asymptomatic cases. Associations were stronger when analysis was restricted to cases who had undergone cholecystectomy. Conclusions: In this prospective cohort of male US health professionals, higher adherence to the aMed, AHEI-2010 and DASH diets was associated with lower risk of symptomatic gallstone disease. Dietary recommendations focusing on high-quality diets targeting symptomatic gallstone disease may lower the incidence of this prevalent disease.

Indexed as

Diet, HealthyDiet, MediterraneanAdultAgedBody Mass IndexGallstonesHealth PersonnelHumansIncidenceMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsUnited States

Identifiers

PMID30312404
PMCPMC6280928
OpenAlexW2898050588

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.