Evidence map›Paper›PMID 30312365›Full record

ArticleAmerican journal of epidemiology2019

Addressing Gaps in HIV Preexposure Prophylaxis Care to Reduce Racial Disparities in HIV Incidence in the United States.

Samuel M Jenness, Kevin M Maloney, Dawn K Smith, Karen W Hoover, Steven M Goodreau, Eli S Rosenberg, Kevin M Weiss, Albert Y Liu, Darcy W Rao, Patrick S Sullivan

Abstract read
In one paragraph

Article in American journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. NIH Investment in HIV and Implementation Science.Journal of the International AIDS Society · 2026
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  15. The Future of HIV: Challenges in meeting the 2030medRxiv : the preprint server for health sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Samuel M JennessDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Kevin M MaloneyDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Dawn K SmithDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Karen W HooverDivision of HIV/AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Steven M GoodreauDepartment of Anthropology, University of Washington, Seattle, Washington.
Eli S RosenbergDepartment of Epidemiology and Biostatistics, School of Public Health, University of Albany, Albany, New York.
Kevin M WeissDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.
Albert Y LiuBridge HIV, Population Health Division, San Francisco Department of Public Health, San Francisco, California.
Darcy W RaoDepartment of Epidemiology, School of Public Health, University of Washington, Seattle, Washington.
Patrick S SullivanDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

Funding

University of Washington/Fred Hutch Center for AIDS ResearchP30AI027757 · NIAID · UNIVERSITY OF WASHINGTON · PI EDWIN ROBERTO ORELLANA · 1988 to 2026
$104.9M
Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
VENEREAL DISEASET32AI007140 · NIAID · UNIVERSITY OF WASHINGTON · PI Julia Cook Dombrowski · 1985 to 2026
$19.4M
Scientific/Technical CoreP2CHD042828 · NICHD · UNIVERSITY OF WASHINGTON · PI SARA R. CURRAN · 2017 to 2026
$6.3M
ENHANCING MODELS OF HIV, VIRAL HEPATITIS, STIs, AND TUBERCULOSIS TO INFORM AND IMPROVE PUBLIC HEALTH IMPACTU38PS004646 · PS · EMORY UNIVERSITY · PI SULLIVAN, PATRICK · 2014 to 2015
$2.9M
Modeling Antiretroviral-Based Prevention among MSM in the USR21MH112449 · NIMH · EMORY UNIVERSITY · PI JENNESS, SAMUEL · 2017 to 2018
$442k
Using Sexual Network Transmission Models to Explain HIV Disparities Between BlackR21HD075662 · NICHD · UNIVERSITY OF WASHINGTON · PI GOODREAU, STEVEN M. · 2013 to 2014
$418k
NCHHSTP CDC HHS U38 PS004646NIAID NIH HHS P30 AI027757NIAID NIH HHS P30 AI050409NIAID NIH HHS T32 AI007140NICHD NIH HHS P2C HD042828NICHD NIH HHS R21 HD075662NIMH NIH HHS R21 MH112449
6 · The paper itself

Abstract

The potential for human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP) to reduce the racial disparities in HIV incidence in the United States might be limited by racial gaps in PrEP care. We used a network-based mathematical model of HIV transmission for younger black and white men who have sex with men (BMSM and WMSM) in the Atlanta, Georgia, area to evaluate how race-stratified transitions through the PrEP care continuum from initiation to adherence and retention could affect HIV incidence overall and disparities in incidence between races, using current empirical estimates of BMSM continuum parameters. Relative to a no-PrEP scenario, implementing PrEP according to observed BMSM parameters was projected to yield a 23% decline in HIV incidence (hazard ratio = 0.77) among BMSM at year 10. The racial disparity in incidence in this observed scenario was 4.95 per 100 person-years at risk (PYAR), a 19% decline from the 6.08 per 100 PYAR disparity in the no-PrEP scenario. If BMSM parameters were increased to WMSM values, incidence would decline by 47% (hazard ratio = 0.53), with an associated disparity of 3.30 per 100 PYAR (a 46% decline in the disparity). PrEP could simultaneously lower HIV incidence overall and reduce racial disparities despite current gaps in PrEP care. Interventions addressing these gaps will be needed to substantially decrease disparities.

Indexed as

AdultAnti-HIV AgentsBlack or African AmericanGeorgiaHealth Status DisparitiesHIV InfectionsHomosexuality, MaleHumansIncidenceMalePre-Exposure ProphylaxisSexual and Gender MinoritiesUnited StatesWhite PeopleYoung AdultAnti-HIV Agentshuman immunodeficiency virusmathematical modelmen who have sex with menpreexposure prophylaxisracial disparities

Identifiers

PMID30312365
PMCPMC6438815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.