Observational studyPloS one2018
Functional network connectivity is altered in patients with upper limb somatosensory impairments in the acute phase post stroke: A cross-sectional study.
Observational study in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of oral frailty prevalence among older hospitalized patients.Frontiers in public health · 2025Pooled it
- Functional Disconnections of the Pre-Supplementary Motor Area in Patients With Post-Stroke Aphasia and Their Associations With Neurotransmitters.CNS neuroscience & therapeutics · 2025Article
- Altered Static and Dynamic Functional Network Connectivity and Combined Machine Learning in Stroke.Brain topography · 2025Article
- Research Progress on Neural Processing of Hand and Forearm Tactile Sensation: A Review Based on fMRI Research.Neuropsychiatric disease and treatment · 2025Review
- Article
- Relationship between resting-state functional connectivity and change in motor function after motor imagery intervention in patients with stroke: a scoping review.Journal of neuroengineering and rehabilitation · 2023Article
- Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients.Scientific reports · 2022Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Resting State Connectivity Is Modulated by Motor Learning in Individuals After Stroke.Neurorehabilitation and neural repair · 2021Article
- Brain Functional Changes in Stroke Following Rehabilitation Using Brain-Computer Interface-Assisted Motor Imagery With and Without tDCS: A Pilot Study.Frontiers in human neuroscience · 2021Article
- Brain connectivity alterations after additional sensorimotor or motor therapy for the upper limb in the early-phase post stroke: a randomized controlled trial.Brain communications · 2021Article
- Structural and functional reorganization following unilateral internal capsule infarction contribute to neurological function recovery.Neuroradiology · 2019Article
- A Case Series Clinical Trial of a Novel Approach Using Augmented Reality That Inspires Self-body Cognition in Patients With Stroke: Effects on Motor Function and Resting-State Brain Functional Connectivity.Frontiers in systems neuroscience · 2019Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAberrant functional connectivity in brain networks associated with motor impairment after stroke is well described, but little is known about the association with somatosensory impairments.
aimThe objective of this cross-sectional observational study was to investigate the relationship between brain functional connectivity and severity of somatosensory impairments in the upper limb in the acute phase post stroke.
methodsNineteen first-ever stroke patients underwent resting-state functional magnetic resonance imaging (rs-fMRI) and a standardized clinical somatosensory profile assessment (exteroception and higher cortical somatosensation) in the first week post stroke. Integrity of inter- and intrahemispheric (ipsilesional and contralesional) functional connectivity of the somatosensory network was assessed between patients with severe (Em-NSA< 13/32) and mild to moderate (Em-NSA> 13/32) somatosensory impairments.
resultsPatients with severe somatosensory impairments displayed significantly lower functional connectivity indices in terms of interhemispheric (p = 0.001) and ipsilesional intrahemispheric (p = 0.035) connectivity compared to mildly to moderately impaired patients. Significant associations were found between the perceptual threshold of touch assessment and interhemispheric (r = -0.63) and ipsilesional (r = -0.51) network indices. Additional significant associations were found between the index of interhemispheric connectivity and light touch (r = 0.55) and stereognosis (r = 0.64) evaluation.
conclusionPatients with more severe somatosensory impairments have lower inter- and ipsilesional intrahemispheric connectivity of the somatosensory network. Lower connectivity indices are related to more impaired exteroception and higher cortical somatosensation. This study highlights the importance of network integrity in terms of inter- and ipsilesional intrahemispheric connectivity for somatosensory function. Further research is needed investigating the effect of therapy on the re-establishment of these networks.
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