Evidence map›Paper›PMID 30312118›Full record

Trial reportJournal of women's health (2002)2019

A Randomized Controlled Trial of Exercise to Prevent Bone Loss in Premenopausal Women with Breast Cancer.

Laila S Tabatabai, Joan Bloom, Susan Stewart, Deborah E Sellmeyer

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of women's health (2002), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 4 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 4 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The effects of exercise on the bone health of people with cancer: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Pooled it
  4. Pooled it
  5. Trial
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Considerations of Control Conditions Designs in Randomized Controlled Trials of Exercise Interventions for Cancer Survivors.The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres · 2022
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Laila S Tabatabai1 Division of Endocrinology, Houston Methodist Hospital, Houston, Texas.
Joan Bloom2 Department of Health Policy and Management, School of Public Health, University of California, Berkeley, California.
Susan Stewart3 Department of Public Health Sciences, School of Medicine, University of California, Davis, California.
Deborah E Sellmeyer4 Division of Endocrinology, Gerontology, and Metabolism, Stanford University School of Medicine, Palo Alto, California.
Stanford University · USUniversity of California, Davis · US

Funding

Exercise for Bone Health: Young Breast Cancer SurvivorsR01CA112273 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI BLOOM, JOAN R · 2005 to 2009
$3.5M
NCI NIH HHS R01 CA112273
6 · The paper itself

Abstract

Background/Introduction/Objective: Premenopausal women treated for breast cancer are at high risk for bone loss. This trial examined the effects of a 1-year combined aerobic and resistance exercise program on bone mineral density (BMD) in women treated for premenopausal breast cancer. MATERIALS AND

methodsPremenopausal women (n = 206) age ≤ 55 years at cancer diagnosis who were within two years of receiving adjuvant chemotherapy were randomized to a 12-month exercise program or a control group. BMD was measured by dual-energy X-ray absorptiometry at baseline and after 1 year; blood was drawn for skeletal markers. Change from baseline to end of study was compared within and between treatment groups using paired and unpaired t-tests.

resultsLumbar spine BMD declined in both treatment groups with no significant difference between treatment groups (-0.008 ± 0.003 g/cm

conclusionsAmong women who maintained lean mass, our exercise intervention prevented bone loss; however, our intervention did not prevent bone loss among women who lost muscle mass. Additional investigation into exercise regimens that can prevent both bone and muscle loss may help prevent long-term consequences of premenopausal breast cancer treatment.

Indexed as

ExercisePremenopauseAbsorptiometry, PhotonAdultAntineoplastic AgentsBody CompositionBone DensityBreast NeoplasmsCancer SurvivorsExercise TherapyFemaleHumansLumbar VertebraeLumbosacral RegionMiddle AgedOsteoporosisAntineoplastic AgentsTamoxifenbone densitybone lossbreast cancerexerciseosteoporosispremenopausal

Identifiers

PMID30312118
PMCPMC6343190
OpenAlexW2897983383

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.